User:Yvchen

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Research My current research focuses on developing clinically applicable RNA switches regulated by small molecules such as phenobarbital and tamoxifen. One application of this RNA switch technology is the modulation of transgene expression in primary human T cells, which have been designed to treat medical conditions such as glioblastoma. While T cells expanded ex vivo have shown promise in tumor-targeting therapies, maintaining and controlling the proliferation of engineered T cells in the tumor microenvironment remains a challenge. By implementing regulated RNA switches as regulators of cell proliferation, one could expand the potential of immunotherapy utilizing transgenic T cells to address a wide variety of medical challenges. Contact Information Yvonne Chen 1200 E. California Blvd., California Institute of Technology, MC210-41, Pasadena, CA91125 yvchen@caltech.edu