User:Yvchen: Difference between revisions
No edit summary |
|||
Line 6: | Line 6: | ||
== Contact Information == | == Contact Information == | ||
Yvonne Chen | Yvonne Chen | ||
1200 E. California Blvd. | 1200 E. California Blvd. | ||
California Institute of Technology | California Institute of Technology | ||
MC210-41 | MC210-41 | ||
Pasadena, CA91125 | |||
yvchen@caltech.edu |
Revision as of 12:48, 21 August 2006
Research
My current research focuses on developing clinically applicable RNA switches regulated by small molecules such as phenobarbital and tamoxifen. One application of this RNA switch technology would be the modulation of transgene expression in primary human T cells, which are designed to treat medical conditions such as glioblastoma. While T cells expanded ex vivo have shown promise in tumor-targeting therapies, the possibility of misdirected cytotoxicity poses serious concerns and severely limits their accepted range of application. By implementing regulated RNA switches as an additional safety check, immunotherapy utilizing transgenic T cells could potentially be used to address a wide variety of medical challenges.
Contact Information
Yvonne Chen 1200 E. California Blvd. California Institute of Technology MC210-41 Pasadena, CA91125
yvchen@caltech.edu