User:Yvchen

My current research focuses on developing clinically applicable RNA switches regulated by small molecules such as phenobarbital and tamoxifen. One application of this RNA switch technology would be the modulation of transgene expression in primary human T cells, which are designed to treat medical conditions such as glioblastoma. While T cells expanded ex vivo have shown promise in tumor-targeting therapies, the possibility of misdirected cytotoxicity poses serious concerns and severely limits their accepted range of application. By implementing regulated RNA switches as an additional safety check, immunotherapy utilizing transgenic T cells could potentially be used to address a wide variety of medical challenges.