Van Oudenaarden Lab: Difference between revisions
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'''2005''' | '''2005''' | ||
E. M. Ozbudak, A. Becskei, and A. van Oudenaarden, [http://web.mit.edu/biophysics/papers/DEVCELL2005.pdf A system of counteracting feedback loops regulates Cdc42p actvity during spontaneous cell polarization], Developmental Cell 9, 565 (2005). | *E. M. Ozbudak, A. Becskei, and A. van Oudenaarden, [http://web.mit.edu/biophysics/papers/DEVCELL2005.pdf A system of counteracting feedback loops regulates Cdc42p actvity during spontaneous cell polarization], Developmental Cell 9, 565 (2005). | ||
A. Becskei, B. B. Kaufmann, and A. van Oudenaarden, | *A. Becskei, B. B. Kaufmann, and A. van Oudenaarden,[http://web.mit.edu/biophysics/papers/NG2005.pdf Contributions of low molecule number and chromosomal positioning to stochastic gene expression], Nature Genetics 37, 937 (2005). | ||
[http://web.mit.edu/biophysics/papers/NG2005.pdf Contributions of low molecule number and chromosomal positioning to stochastic gene expression], | |||
Nature Genetics 37, 937 (2005). | |||
M. Acar, A. Becskei, and A. van Oudenaarden, | *M. Acar, A. Becskei, and A. van Oudenaarden,[http://web.mit.edu/biophysics/papers/NATURE2005.pdf Enhancement of cellular memory by reducing stochastic transitions], Nature 435, 228 (2005). | ||
[http://web.mit.edu/biophysics/papers/NATURE2005.pdf Enhancement of cellular memory by reducing stochastic transitions], | |||
Nature 435, 228 (2005). | |||
J. M. Pedraza and A. van Oudenaarden, | *J. M. Pedraza and A. van Oudenaarden, [http://web.mit.edu/biophysics/papers/SCIENCE2005.pdf Noise propagation in gene networks], Science 307, 1965 (2005). | ||
[http://web.mit.edu/biophysics/papers/SCIENCE2005.pdf Noise propagation in gene networks], | |||
Science 307, 1965 (2005). | |||
[http://web.mit.edu/biophysics/papers.html '''''...all publications'''''] | [http://web.mit.edu/biophysics/papers.html '''''...all publications'''''] | ||
== [[Van_Oudenaarden_Lab:Members | Lab members]] == | == [[Van_Oudenaarden_Lab:Members | Lab members]] == | ||
== [[Van_Oudenaarden_Lab:Internal | Internal lab resource]] == | == [[Van_Oudenaarden_Lab:Internal | Internal lab resource]] == | ||
Revision as of 02:36, 11 January 2006
Welcome to the Van Oudenaarden Lab homepage, hosted by OpenWetWare.
Email: avano@mit.edu
Phone: (617) 253-4446
Fax: (617) 258-6883
Address:
77 Massachusetts Ave.
Bldg. 13-2008 (Office)
Bldg. 13-2048, 13-2056, 13-2060 (Labs)
Cambridge, MA 02139
Mission
Living systems are intrinsically noisy. Surprisingly, the functioning of a living organism is not significantly hindered by these random fluctuations. Biological cells can even exploit noise by deliberately introducing diversity into a population. In these cases noise is not a nuisance, but essential for survival. Advances in modern biochemistry and genetics have led to a detailed understanding of the molecular machinery involved in gene expression, and the constant flow of data from the Genome Project has enabled the identification of more and more genes. A millennial challenge is to quantitatively understand how different genes and their regulating proteins are grouped together in genetic circuits, and how stochastic fluctuations influence gene expression in these complex systems. In our group we focus on the importance of noise in the expression of genes by using both experimental and theoretical approaches.
Recent Publications
2005
- E. M. Ozbudak, A. Becskei, and A. van Oudenaarden, A system of counteracting feedback loops regulates Cdc42p actvity during spontaneous cell polarization, Developmental Cell 9, 565 (2005).
- A. Becskei, B. B. Kaufmann, and A. van Oudenaarden,Contributions of low molecule number and chromosomal positioning to stochastic gene expression, Nature Genetics 37, 937 (2005).
- M. Acar, A. Becskei, and A. van Oudenaarden,Enhancement of cellular memory by reducing stochastic transitions, Nature 435, 228 (2005).
- J. M. Pedraza and A. van Oudenaarden, Noise propagation in gene networks, Science 307, 1965 (2005).
