Van Oudenaarden Lab

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77 Massachusetts Ave.
77 Massachusetts Ave.
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Bldg. 13-2008 (Office)  
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Bldg. 68-371B (Office)  
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Bldg. 13-2048, 13-2056, 13-2060 (Labs)  
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Bldg. 68-365, 68-359, 68-383 (Labs)  
Cambridge, MA  02139
Cambridge, MA  02139
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== Recent Publications ==
== Recent Publications ==
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'''2005'''
 
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*E. M. Ozbudak, A. Becskei, and A. van Oudenaarden, [http://web.mit.edu/biophysics/papers/DEVCELL2005.pdf A system of counteracting feedback loops regulates Cdc42p actvity during spontaneous cell polarization], Developmental Cell 9, 565 (2005).
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For our recent publications see
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*A. Becskei, B. B. Kaufmann, and A. van Oudenaarden,[http://web.mit.edu/biophysics/papers/NG2005.pdf Contributions of low molecule number and chromosomal positioning to stochastic gene expression], Nature Genetics 37, 937 (2005).
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*M. Acar, A. Becskei, and A. van Oudenaarden,[http://web.mit.edu/biophysics/papers/NATURE2005.pdf Enhancement of cellular memory by reducing stochastic transitions], Nature 435, 228 (2005).
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*J. M. Pedraza and A. van Oudenaarden, [http://web.mit.edu/biophysics/papers/SCIENCE2005.pdf Noise propagation in gene networks], Science 307, 1965 (2005).
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[http://web.mit.edu/biophysics/papers.html '''''...all publications''''']
[http://web.mit.edu/biophysics/papers.html '''''...all publications''''']

Revision as of 12:39, 24 December 2007

Alexander van Oudenaarden
Alexander van Oudenaarden

Welcome to the van Oudenaarden Lab homepage, hosted by OpenWetWare. Also check out our other lab web-site


Email: avano@mit.edu

Phone: (617) 253-4446

Fax: (617) 258-6883

Address:

77 Massachusetts Ave.

Bldg. 68-371B (Office)

Bldg. 68-365, 68-359, 68-383 (Labs)

Cambridge, MA 02139

Contents

Mission

Living systems are intrinsically noisy. Surprisingly, the functioning of a living organism is not significantly hindered by these random fluctuations. Biological cells can even exploit noise by deliberately introducing diversity into a population. In these cases noise is not a nuisance, but essential for survival. Advances in modern biochemistry and genetics have led to a detailed understanding of the molecular machinery involved in gene expression, and the constant flow of data from the Genome Project has enabled the identification of more and more genes. A millennial challenge is to quantitatively understand how different genes and their regulating proteins are grouped together in genetic circuits, and how stochastic fluctuations influence gene expression in these complex systems. In our group we focus on the importance of noise in the expression of genes by using both experimental and theoretical approaches.

Recent Publications

For our recent publications see

...all publications

Lab members

Internal lab resource

Personal tools