Van Oudenaarden Lab
Welcome to the Van Oudenaarden Lab homepage, hosted by OpenWetWare.
Phone: (617) 253-4446
Fax: (617) 258-6883
77 Massachusetts Ave.
Bldg. 13-2008 (Office)
Bldg. 13-2048, 13-2056, 13-2060 (Labs)
Cambridge, MA 02139
Living systems are intrinsically noisy. Surprisingly, the functioning of a living organism is not significantly hindered by these random fluctuations. Biological cells can even exploit noise by deliberately introducing diversity into a population. In these cases noise is not a nuisance, but essential for survival. Advances in modern biochemistry and genetics have led to a detailed understanding of the molecular machinery involved in gene expression, and the constant flow of data from the Genome Project has enabled the identification of more and more genes. A millennial challenge is to quantitatively understand how different genes and their regulating proteins are grouped together in genetic circuits, and how stochastic fluctuations influence gene expression in these complex systems. In our group we focus on the importance of noise in the expression of genes by using both experimental and theoretical approaches.
2005 E. M. Ozbudak, A. Becskei, and A. van Oudenaarden, A system of counteracting feedback loops regulates Cdc42p actvity during spontaneous cell polarization, Developmental Cell 9, 565 (2005).
A. Becskei, B. B. Kaufmann, and A. van Oudenaarden, Contributions of low molecule number and chromosomal positioning to stochastic gene expression, Nature Genetics 37, 937 (2005).
M. Acar, A. Becskei, and A. van Oudenaarden, =http://web.mit.edu/biophysics/papers/NATURE2005.pdf Enhancement of cellular memory by reducing stochastic transitions], Nature 435, 228 (2005).
J. M. Pedraza and A. van Oudenaarden, Noise propagation in gene networks, Science 307, 1965 (2005).
This is the unofficial homepage of the Van Oudenaarden biophysics lab, hosted on OpenWetWare. The official page is here.
Group member should feel free to make major revisions to this page to help get it off the ground. Getting_Started_on_OpenWetWare will explain how to make a new page and what you might want to put on it. Ask User:Mokelly to set up your account.
Lab members (add yourself to this list when you get an account)
- Michael J.T. O'Kelly - User:Mokelly
- Murat Acar - User:Murat
- John Tsang - User:tsang
- Bernardo Pando - User:ber