Veit-Simon Eckle

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|valign="top" | [[Image:Eckle.jpg|left]]  
|valign="top" | [[Image:Eckle.jpg|left]]  
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|valign="top" | [mailto:veit-simon.eckle@uni-tuebingen.de Dr. Veit-Simon Eckle]<br>
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|valign="top" | [mailto:veit-simon.eckle@uni-tuebingen.de Dr.&nbsp;Veit-Simon&nbsp;Eckle]<br>
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Schaffhausenstr.&nbsp;113<br>
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Waldhörnlestr.&nbsp;22<br>
D-72072&nbsp;Tübingen<br>
D-72072&nbsp;Tübingen<br>
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Tel.&nbsp;++49-7071/7&nbsp;93&nbsp;62&nbsp;17<br>
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Tel.&nbsp;++49-7071/29&nbsp;8&nbsp;11&nbsp;59<br>
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Fax&nbsp;++49-7071/36&nbsp;51&nbsp;09<br>
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Fax&nbsp;++49-7071/29&nbsp;2&nbsp;50&nbsp;73<br>
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|-
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| valign="top" |'''Residency:'''
| valign="top" |'''Residency:'''
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|valign="top" | Department of Anesthesiology, University of Tübingen<br>
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|valign="top" | [http://www.medizin.uni-tuebingen.de/Patienten/Kliniken/Anaesthesiologie+und+Intensivmedizin.html Department of Anesthesiology], [http://www.uni-tuebingen.de University of Tübingen]<br>
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Department of Anesthesiology, Klinikum rechts der Isar, Munich<br>
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[http://www.mri.tum.de/anaesthesie Department of Anesthesiology], [http://www.med.tum.de/ Klinikum rechts der Isar], Munich<br>
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Department of Anesthesiology, Brüderkrankenhaus Trier<br>
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[http://www.bk-trier.de/bk_trier/Medizin-Pflege/fachabteilungen/anaesthesie/index.php Department of Anesthesiology], [http://www.bk-trier.de/bk_trier/index.php Brüderkrankenhaus Trier]<br>
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| valign="top" | '''Fellowship:'''
| valign="top" | '''Fellowship:'''
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|valign="top" | Research Associate in Anesthesiology, University of Virginia  
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|valign="top" | Research Associate, Department of Anesthesiology (Prof. SM. Todorovic, [http://www.medicine.virginia.edu/clinical/departments/anesthesiology/research/slobodan-todorovic.html Todorovic Lab]) and Pharmacology (Prof. E. Perez Reyes [http://people.virginia.edu/~ebp8n/ Perez-Reyes Lab]), [http://www.virginia.edu/ University of Virginia], Charlottesville, Virginia, USA<br> 
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| valign="top" | '''Research Interests:'''  
| valign="top" | '''Research Interests:'''  
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| valign="top" | Voltage-gated Ca2+ channels (T-type), anesthetic effects on molecular targets in neuronal networks
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| valign="top" | Anesthetic effects on molecular targets in neuronal networks, GABAA and glycine receptors, voltage-gated Ca2+ channels (T-type), two-pore-potassium channels (TREK), spinal cord
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|-
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| valign="top" | '''Methods:'''
| valign="top" | '''Methods:'''
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| valign="top" | Current clamp recordings in cell-attached and whole-cell mode, voltage clamp recordings, inside-out-configuration, spinal cultured neurons, brain slice technique  
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| valign="top" | Current clamp recordings in cell-attached and whole-cell mode, voltage clamp recordings, inside-out-configuration, cultured spinal neurons, brain slice technique  
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|-
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|
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| valign="top" | '''Awards: '''
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| valign="top" |3rd Prize, oral presentation competition: "Propofol modulates rather phasic than tonic GABAergic currents in the spinal ventral horn", 14th Capital City Conference of the [http://www.dgai.de/ DGAI], Congress of Anesthesiology and Intensive Care Medicine, September 2012<br>
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[http://www.wakwin.de/tiki-index.php WAKWIN] Mentee, [http://www.dgai.de/ German Society for Anaesthesiology and Intensive Care], 2010<br>
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Resident Travel Award, [http://www.snacc.org/ SNACC] Meeting, Orlando 2008
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| valign="top" | '''Patent: '''
| valign="top" | '''Patent: '''
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| valign="top" |Intrajugular balloon catheter for prevention of air embolism" (DE102011106676.8)
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| valign="top" |Intrajugular balloon catheter for prevention of air embolism (DE102011106676.8)
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|-
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|
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| valign="top" | '''Professional Societies: '''
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| valign="top" |[http://www.dgai.de/ German Society for Anaesthesiology and Intensive Care]<br>[http://www.euroanaesthesia.org/ European Society of Anaesthesiology]
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=== Selected Publications: ===
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==== Selected Publications: ====
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Eckle VS, Grasshoff C. Intrajugular balloon catheter for prevention of air embolism. J Neurosurg Anesthesiol. 2011 Nov 29. [Epub ahead of print]<br>
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* Eckle VS, Digruccio MR, Uebele VN, Renger JJ, Todorovic SM. Inhibition of T-type calcium current in rat thalamocortical neurons by isoflurane. Neuropharmacology. 2012 Aug;63(2):266-73 [http://www.ncbi.nlm.nih.gov/pubmed/22491022 PubMed]
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Choe W, Messinger RB, Leach E, Eckle VS, Obradovic A, Salajegheh R, Jevtovic-Todorovic V, Todorovic SM. TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent. Mol Pharmacol. 2011;80:900-10.<br>
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* Eckle VS, Grasshoff C. Intrajugular balloon catheter for prevention of air embolism. J Neurosurg Anesthesiol. 2012 Jan;24(1):81-2. [http://www.ncbi.nlm.nih.gov/pubmed/22134411 PubMed]
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Eckle VS, Todorovic SM. Mechanisms of inhibition of CaV3.1 T-type calcium current by aliphatic alcohols. Neuropharmacology. 2010;59:58-69.<br>
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* Choe W, Messinger RB, Leach E, Eckle VS, Obradovic A, Salajegheh R, Jevtovic-Todorovic V, Todorovic SM. TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent. Mol Pharmacol. 2011;80:900-10. [http://www.ncbi.nlm.nih.gov/pubmed/21821734 PubMed]
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Haseneder R, Kratzer S, Kochs E, Eckle VS, Zieglgänsberger W, Rammes G. Xenon reduces N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated synaptic transmission in the amygdala. Anesthesiology. 2008;109:998-1006.<br>
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* Eckle VS, Todorovic SM. Mechanisms of inhibition of CaV3.1 T-type calcium current by aliphatic alcohols. Neuropharmacology. 2010;59:58-69. [http://www.ncbi.nlm.nih.gov/pubmed/20363234 PubMed]
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Eckle VS, Buchmann A, Bursch W, Schulte-Hermann R, Schwarz M. Immunohistochemical detection of activated caspases in apoptotic hepatocytes in rat liver. Toxicol Pathol. 2004;32:9-15.|}
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* Eckle VS, Hucklenbruch C, Todorovic SM. What do we know about anesthetic mechanisms?: hypnosis, unresponsiveness to surgical incision and amnesia. Anaesthesist. 2009 Nov;58(11):1144-9. [http://www.ncbi.nlm.nih.gov/pubmed/19760252 PubMed]
 +
* Haseneder R, Kratzer S, Kochs E, Eckle VS, Zieglgänsberger W, Rammes G. Xenon reduces N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated synaptic transmission in the amygdala. Anesthesiology. 2008;109:998-1006. [http://www.ncbi.nlm.nih.gov/pubmed/19034096 PubMed]
 +
* Eckle VS, Buchmann A, Bursch W, Schulte-Hermann R, Schwarz M. Immunohistochemical detection of activated caspases in apoptotic hepatocytes in rat liver. Toxicol Pathol. 2004;32:9-15. [http://www.ncbi.nlm.nih.gov/pubmed/14713542 PubMed]

Revision as of 13:49, 6 February 2013

Home        Forschung        Lehre        Publikationen        Poster        Mitarbeiter        Dissertationen        Kooperationen  


Lebenslauf

Dr. Veit-Simon Eckle

Waldhörnlestr. 22
D-72072 Tübingen
Tel. ++49-7071/29 8 11 59
Fax ++49-7071/29 2 50 73

Residency: Department of Anesthesiology, University of Tübingen

Department of Anesthesiology, Klinikum rechts der Isar, Munich
Department of Anesthesiology, Brüderkrankenhaus Trier

Fellowship: Research Associate, Department of Anesthesiology (Prof. SM. Todorovic, Todorovic Lab) and Pharmacology (Prof. E. Perez Reyes Perez-Reyes Lab), University of Virginia, Charlottesville, Virginia, USA
Research Interests: Anesthetic effects on molecular targets in neuronal networks, GABAA and glycine receptors, voltage-gated Ca2+ channels (T-type), two-pore-potassium channels (TREK), spinal cord
Methods: Current clamp recordings in cell-attached and whole-cell mode, voltage clamp recordings, inside-out-configuration, cultured spinal neurons, brain slice technique
Awards: 3rd Prize, oral presentation competition: "Propofol modulates rather phasic than tonic GABAergic currents in the spinal ventral horn", 14th Capital City Conference of the DGAI, Congress of Anesthesiology and Intensive Care Medicine, September 2012

WAKWIN Mentee, German Society for Anaesthesiology and Intensive Care, 2010
Resident Travel Award, SNACC Meeting, Orlando 2008

Patent: Intrajugular balloon catheter for prevention of air embolism (DE102011106676.8)
Professional Societies: German Society for Anaesthesiology and Intensive Care
European Society of Anaesthesiology

Selected Publications:

  • Eckle VS, Digruccio MR, Uebele VN, Renger JJ, Todorovic SM. Inhibition of T-type calcium current in rat thalamocortical neurons by isoflurane. Neuropharmacology. 2012 Aug;63(2):266-73 PubMed
  • Eckle VS, Grasshoff C. Intrajugular balloon catheter for prevention of air embolism. J Neurosurg Anesthesiol. 2012 Jan;24(1):81-2. PubMed
  • Choe W, Messinger RB, Leach E, Eckle VS, Obradovic A, Salajegheh R, Jevtovic-Todorovic V, Todorovic SM. TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent. Mol Pharmacol. 2011;80:900-10. PubMed
  • Eckle VS, Todorovic SM. Mechanisms of inhibition of CaV3.1 T-type calcium current by aliphatic alcohols. Neuropharmacology. 2010;59:58-69. PubMed
  • Eckle VS, Hucklenbruch C, Todorovic SM. What do we know about anesthetic mechanisms?: hypnosis, unresponsiveness to surgical incision and amnesia. Anaesthesist. 2009 Nov;58(11):1144-9. PubMed
  • Haseneder R, Kratzer S, Kochs E, Eckle VS, Zieglgänsberger W, Rammes G. Xenon reduces N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated synaptic transmission in the amygdala. Anesthesiology. 2008;109:998-1006. PubMed
  • Eckle VS, Buchmann A, Bursch W, Schulte-Hermann R, Schwarz M. Immunohistochemical detection of activated caspases in apoptotic hepatocytes in rat liver. Toxicol Pathol. 2004;32:9-15. PubMed
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