WFPink Proposal: Difference between revisions
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* '''"Paper 2":''' Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WSN-4WH1GC7-C&_user=501045&_coverDate=06%2F12%2F2009&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000022659&_version=1&_urlVersion=0&_userid=501045&md5=1aa432d2843456eb7375e492ce6c2605) | * '''"Paper 2":''' Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WSN-4WH1GC7-C&_user=501045&_coverDate=06%2F12%2F2009&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000022659&_version=1&_urlVersion=0&_userid=501045&md5=1aa432d2843456eb7375e492ce6c2605) | ||
* '''"That Review Article We Can't Get Yet"''': MicroRNAs in Cancer: Small Molecules with a Big Impact (http://jco.ascopubs.org/cgi/content/abstract/JCO.2009.24.0317v1) | * '''"That Review Article We Can't Get Yet"''': MicroRNAs in Cancer: Small Molecules with a Big Impact (http://jco.ascopubs.org/cgi/content/abstract/JCO.2009.24.0317v1) | ||
* '''"Other Review Article We Can't Get"''': Assaying microRNA loss-of-function phenotypes in mammalian cells: Emerging tools and their potential therapeutic utility (http://www.landesbioscience.com/journals/rnabiology/article/10081) | |||
Revision as of 14:37, 18 November 2009
Katie Thomas and Kristin Kuhn
Using MicroRNAs to treat cancer
(Optionally including a way to deliver microRNAs specifically to cancer cells)
Project Overview
MicroRNAs are an up-and-coming field of biology. Recent research has shown that they have a critical role in many types of cancers, both as oncogenes and as tumor-suppressors. Much work has gone into investigating the possibility of using miRNAs to treat cancer.
Background Info
- "expression level of microRNAs are altered in most human cancers"
Research Problem
- Investigate using miRNAs to knock out genes (like p53) that are known to cause cancer.
- Or, investigate how to regulate over-active miRNAs that cause cancers themselves.
- Or, investigate how miRNAs work by knocking out known miRNA sequences and seeing what happens. Maybe mutating them? Can we change their specificity?
Project Details and Methods
Predicted Outcomes
Needed Resources
e.g., financial, cell stocks, etc
(Possible) Sources
- "Paper 1": ERα-negative and triple negative breast cancer: Molecular features and potential therapeutic approaches (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T23-4WHFD55-1&_user=501045&_coverDate=12%2F31%2F2009&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000022659&_version=1&_urlVersion=0&_userid=501045&md5=59d0f4727e262100e250780b97e3126f)
- "Paper 2": Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WSN-4WH1GC7-C&_user=501045&_coverDate=06%2F12%2F2009&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000022659&_version=1&_urlVersion=0&_userid=501045&md5=1aa432d2843456eb7375e492ce6c2605)
- "That Review Article We Can't Get Yet": MicroRNAs in Cancer: Small Molecules with a Big Impact (http://jco.ascopubs.org/cgi/content/abstract/JCO.2009.24.0317v1)
- "Other Review Article We Can't Get": Assaying microRNA loss-of-function phenotypes in mammalian cells: Emerging tools and their potential therapeutic utility (http://www.landesbioscience.com/journals/rnabiology/article/10081)
