WFYellow(F08) Research Proposal

From OpenWetWare

(Difference between revisions)
Jump to: navigation, search
(Allen and Jess's 20.109 Module 3 Research Proposal Resource Page)
Line 1: Line 1:
==[[User:Allen Lin | Allen]] and [[User:Jessho | Jess's]] 20.109 Module 3 Research Proposal Resource Page==
==[[User:Allen Lin | Allen]] and [[User:Jessho | Jess's]] 20.109 Module 3 Research Proposal Resource Page==
-
<b>Idea:</b>  
+
<b>Idea(s):</b>  
-
Identify proteins associated with extracellular Hsp90 (in particular HER-2/ErbB2)
+
Identify proteins associated with extracellularlly-presented Hsp90 (in particular HER-2/ErbB2), which is known to be over-expressed in proliferating cancer cells.
 +
 
 +
High membrane-bound Hsp90 expression also correlates with the rounded morphology of proliferative cancer.  One potential research idea is to study the induction of flat vs. rounded morphology pathways and observe whether or not return of flattened morphology reduces cell proliferation, metastasis, and tissue invasion.
<b>Links to papers</b>
<b>Links to papers</b>

Revision as of 13:59, 19 November 2008

Allen and Jess's 20.109 Module 3 Research Proposal Resource Page

Idea(s): Identify proteins associated with extracellularlly-presented Hsp90 (in particular HER-2/ErbB2), which is known to be over-expressed in proliferating cancer cells.

High membrane-bound Hsp90 expression also correlates with the rounded morphology of proliferative cancer. One potential research idea is to study the induction of flat vs. rounded morphology pathways and observe whether or not return of flattened morphology reduces cell proliferation, metastasis, and tissue invasion.

Links to papers

  1. Cid C, Regidor I, Poveda PD, and Alcazar A. . pmid:18800240. PubMed HubMed [cid08]
  2. Sidera K, Gaitanou M, Stellas D, Matsas R, and Patsavoudi E. . pmid:18056992. PubMed HubMed [sidera-jcb-2008]
  3. Eustace BK, Sakurai T, Stewart JK, Yimlamai D, Unger C, Zehetmeier C, Lain B, Torella C, Henning SW, Beste G, Scroggins BT, Neckers L, Ilag LL, and Jay DG. . pmid:15146192. PubMed HubMed [eustace04]
  4. Sidera K and Patsavoudi E. . pmid:18469526. PubMed HubMed [sidera08]
  5. Eustace BK and Jay DG. . pmid:15326368. PubMed HubMed [eustace04b]
  6. Tsutsumi S and Neckers L. . pmid:17645779. PubMed HubMed [tsutsumi07]
All Medline abstracts: PubMed HubMed

Methods
cell fractionstion
TAP (or other)-tagging

Personal tools