WUSM Microbes and Pathogenesis Wiki: Adenovirus Group 9: Difference between revisions
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=Adenovirus= | =Adenovirus= | ||
==Entry (Laura)== | |||
Adenovirus enters the host cell by two coordinated mechanisms. First, the virus adheres to the host cell by binding of adenovirus fiber protein to the host cell receptor. The fiber protein contains three domains: an N-terminal tail that interacts with the penton base, a central shaft domain, and a C-terminal globular domain. Host cell surface receptors include CD46 and CAR (Coxsackievirus Adenovirus Receptor). CD46 acts as the receptor for the group B human adenovirus serotypes, while CAR is the receptor for all other known serotypes. MHC molecules and sialic acid residues may also contribute to adherence. | |||
After initial binding, a motif in the adenovirus penton base protein interacts with an αv integrin co-receptor on the host cell surface. Attachment to the αv integrin induces actin polymerization, resulting in endocytosis of adenovirus into the host cell via clathrin-coated pits. The virus then escapes from the endosome and enters the nuclear pore complex. Viral DNA is then transported to the nucleus, where gene expression, viral replication and assembly can occur. | |||
Wu and Nemerow (2004). “Virus yoga: the role of flexibility in virus host cell recognition”. Trends Microbiology 12: 162-168. |
Revision as of 14:59, 22 February 2010
Spring of 2010
Adenovirus
Entry (Laura)
Adenovirus enters the host cell by two coordinated mechanisms. First, the virus adheres to the host cell by binding of adenovirus fiber protein to the host cell receptor. The fiber protein contains three domains: an N-terminal tail that interacts with the penton base, a central shaft domain, and a C-terminal globular domain. Host cell surface receptors include CD46 and CAR (Coxsackievirus Adenovirus Receptor). CD46 acts as the receptor for the group B human adenovirus serotypes, while CAR is the receptor for all other known serotypes. MHC molecules and sialic acid residues may also contribute to adherence.
After initial binding, a motif in the adenovirus penton base protein interacts with an αv integrin co-receptor on the host cell surface. Attachment to the αv integrin induces actin polymerization, resulting in endocytosis of adenovirus into the host cell via clathrin-coated pits. The virus then escapes from the endosome and enters the nuclear pore complex. Viral DNA is then transported to the nucleus, where gene expression, viral replication and assembly can occur.
Wu and Nemerow (2004). “Virus yoga: the role of flexibility in virus host cell recognition”. Trends Microbiology 12: 162-168.