Wang:Research

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<center><font face="lucida fax" style= "color:yellow" size="+10">'''Qianben Wang Laboratory'''</font>
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[[Wang | <font face="trebuchet ms" style="color:#ffffff"> '''Home''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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[[Wang:Research | <font face="trebuchet ms" style="color:#ffffff"> '''Research''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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[[Wang:Publications | <font face="trebuchet ms" style="color:#ffffff"> '''Publications''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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<center><font face="lucida fax" style= "color:yellow" size="+2">'''Laboratory of Cancer Epigenomics'''</font></center>
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<center><font face="lucida fax" style= "color:yellow" size="+1">'''Department of Molecular and Cellular Biochemistry, The Ohio State University'''</font>
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[[Wang | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Home''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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[[Wang:Research | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Research''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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My laboratory is interested in understanding the molecular pathological mechanisms underlying the development and progression of prostate cancer. The androgen receptor (AR), a ligand-dependent transcription factor belonging to the nuclear hormone receptor (NR) superfamily, plays a critical role in the onset and progression of prostate cancer. Recently, we have mapped AR binding regions in the entire human genome in prostate cancer cells by using genome-wide chromatin immunoprecipitation (ChIP) techniques. Through an integrated analysis of AR binding and gene expression data, we have begun to understand how AR regulates target genes involved in prostate cancer growth. Currently, we are extending our view from transcriptional regulation by AR to wider transcriptional regulations in prostate cancer including studying combinatorial transcriptional regulation by AR, its collaborating transcription factors, and its coactivators. We will also apply global ChIP techniques to clinical samples obtained from different stages of prostate cancer. This would allow identification of critical cis-regulatory sequences contributing to prostate cancer progression.
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Current revision

Qianben Wang Laboratory


Laboratory of Cancer Epigenomics


Department of Molecular and Cellular Biochemistry, The Ohio State University


Home              Research              Publications              Lab Members              Contact              News              Gallery

My laboratory is interested in understanding the molecular pathological mechanisms underlying the development and progression of prostate cancer. The androgen receptor (AR), a ligand-dependent transcription factor belonging to the nuclear hormone receptor (NR) superfamily, plays a critical role in the onset and progression of prostate cancer. Recently, we have mapped AR binding regions in the entire human genome in prostate cancer cells by using genome-wide chromatin immunoprecipitation (ChIP) techniques. Through an integrated analysis of AR binding and gene expression data, we have begun to understand how AR regulates target genes involved in prostate cancer growth. Currently, we are extending our view from transcriptional regulation by AR to wider transcriptional regulations in prostate cancer including studying combinatorial transcriptional regulation by AR, its collaborating transcription factors, and its coactivators. We will also apply global ChIP techniques to clinical samples obtained from different stages of prostate cancer. This would allow identification of critical cis-regulatory sequences contributing to prostate cancer progression.

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