Wikiomics:Multiple sequence alignment

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Multiple sequence alignment is widely used in the sequence analysis. It is more reliable, and hosts more information than derived from BLAST multiple pairwise alignment. The MSA allows for identification of common regions between proteins (including motifs), finding conserved residues and analysis of evolutionary relationships between sequences.

Contents

Software producing the multiple sequence alignment

  • Clustal [1]
  • T-Coffee
  • Probcons [2]
  • Muscle [3]
  • MAFFT [4]
  • Kalign [5]
  • PCMA [6]
  • TBA
  • MultiSeq [7]

Analysis of conservation in the multiple sequence alignment

  • AL2CO

Databases of multiple sequence alignments

  • PFAM
  • InterPro
  • CDD

References

Error fetching PMID 7984417:
Error fetching PMID 11524371:
Error fetching PMID 15034147:
Error fetching PMID 15687296:
Error fetching PMID 15661851:
Error fetching PMID 16343337:
Error fetching PMID 12584134:
Error fetching PMID 16914055:
  1. Error fetching PMID 7984417: [clustalw]
  2. Error fetching PMID 15687296: [probcons]
  3. Error fetching PMID 15034147: [muscle]
  4. Error fetching PMID 15661851: [mafft]
  5. Error fetching PMID 16343337: [kalign]
  6. Error fetching PMID 12584134: [pcma]
  7. Error fetching PMID 16914055: [multiseq]
  8. Error fetching PMID 11524371: [al2co]
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