X-Lab

X-Laboratory

(跨膜与感觉信号转导研究组)

Principle Investigator: Xiaodong LIU, Ph.D. (刘晓冬)

Department of Biomedical Engineering, School of Medicine
School of Life Sciences
at Tsinghua University

---

---

Home|主页 Research|研究 People|成员 Publications|发表 Resources|资源 Links|链接 Contact|联系

Welcome to the X-Lab! LAB DESCRIPTION Our lab is broadly interested in transmembrane and sesnory signaling based on channels, pursuing both biophysical mechanisms and bioengineering innovations. One of the most important signaling pathways to convey information from external world into biological systems is by way of channels sitting across the membrane. Such channels: could be cued either by physical (e.g. voltage or photons) or by chemical signals (e.g. small molecules or ions); could be either natural channels (e.g. ion channels conductive to Ca2+ or K+) or engineered channels (e.g., nanopores by ultrasound). We mainly focus on fundamental mechanisms critical to channel complexes involved in transmembrane signaling, especially those related to sensory functions, such as vision and taste. Representative work toward this direction refers to Liu X. et. al. Nature. Meanwhile, we actively explore the potentials of novel methodologies developped or derived from our basic research, such as sonoporation, channel modulators, biomolecular sensors etc. relevant publications Updates 55th Annual Meeting of Biophysical Society March 5 - 9, 2011 http://www.biophysics.org/2011meeting 2nd COLD SPRING HARBOR ASIA CONFERENCES - Membrane Proteins: Structure & Function May 16 - 20, 2011 (CSH) http://www.csh-asia.org/membrane11.html 17th “International Symposium on Calcium-Binding Proteins and Calcium Function in Health and Disease” (CaBP17) http://www.ciccst.org.cn/CaBP/welcome.html Journal Club 2010 ZHANG Yue 8/12 FRET-based FMT XU Yanyan 9/10 GPCR/Sensory Neuron ZHAO Shan (from Du Lab) 9/25 Remotely Triggerable Drug Delivery Systems LIU Qing 10/15 reversible photoswitchable rsTagRFP for pcFRET YU Tao (from Song Lab) 10/22 Tetracycline-regulatable factors with distinct dimerization domains allow reversible growth inhibition by p16 TSE Yan Franco (XIE Xin) 10/29 Calcium Channels NIU Pengxia (from DU Lab) 11/5 fuorescent structural DNA nanoballs functionalized with phsphate-linked nuceotide triphosphates LI Xuesong (from SONG Lab) 11/19 global and local fmri signals driven by neurons defined optogenetically by type and writing Claudia Wittkowske (from DU Lab) 11/26 "Glioblastoma stem-like cells give rise to tumour endothelium" XUE Wenwen 12/10 bacteria magnetosome YU Tao (from SONG Lab) 12/17 optical dimerization XU Yanyan 12/24 Functional connectivity in the retina at the resolution of photoreceptors 2011 ZHAO Shan (from Du Lab) 1/7 Mimicking nature by codelivery of stimulant and inhibitor to create temporally stable and spatially restricted angiogenic zones <New Update> LI Xuesong (from SONG Lab) 2/25 "Genetic dissection of an amygdala microcircuit that gates conditioned fear" and "Encoding of conditioned fear in central amygdala inhibitory circuits" X-LAB. The following positions are currently available: Postdoctoral Fellows: 2 positions; Technician: 1 position; Ph.D. Students: N/A; Masters' Students: 1 or 2 positions. Please send email to Dr. Liu if you are interested. Include your CV and a brief description of your career goals. We also welcome undergraduate students (especially from major research universities in Beijing) to conduct research in our lab on thesis projects. All above positions can start immediately.