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'''X-Laboratory'''  </font> <br>  
'''X-Laboratory'''  </font> <br>  


(跨膜与感觉信号转导研究组) <br>
(跨膜信号研究组) <br>


Principle Investigator: [http://openwetware.org/wiki/User:Xiaodong_Liu Xiaodong LIU, Ph.D. (刘晓冬)]
Principle Investigator: [http://openwetware.org/wiki/User:Xiaodong_Liu Xiaodong LIU, Ph.D. (刘晓冬)]
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[http://bme.med.tsinghua.edu.cn Department of Biomedical Engineering], [http://www.tsinghua.edu.cn/docsn/yxy/English/index_eng.html School of Medicine]
[http://bme.med.tsinghua.edu.cn Department of Biomedical Engineering], [http://www.tsinghua.edu.cn/docsn/yxy/English/index_eng.html School of Medicine]
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[http://mcgovern.med.tsinghua.edu.cn IDG/McGovern Institute for Brain Research]
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[http://life.tsinghua.edu.cn/english School of Life Sciences]  
[http://life.tsinghua.edu.cn/english School of Life Sciences]  
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[[X-Lab|Home]]|[[X-Lab|主页]]
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[[X:News|News]]|[[X:新闻动态|新闻动态]]
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[[X:Research|Research]]|[[X:研究|研究]]
[[X:Research|Research]]|[[X:研究|研究]]
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[[X:People|People]]|[[X:成员|成员]]
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[[X:Publications|Publications]]|[[X:发表|发表]]
[[X:Publications|Publications]]|[[X:发表|发表]]
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[[X:Links|Links]]|[[X:链接|链接]]
[[X:Links|Links]]|[[X:链接|链接]]
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[[X:Internal|Internal]]|[[X:内部|内部]]
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[[X:Contact|Contact]]|[[X:联系|联系]]
[[X:Contact|Contact]]|[[X:联系|联系]]
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LAB DESCRIPTION
LAB DESCRIPTION


Our lab is broadly interested in transmembrane and sensory signaling based on channels, pursuing both biophysical mechanisms and bioengineering innovations.
Our research has been in the field of '''ion channels''', focusing on '''subthreshold or non-spiking behaviors''' and favoring concepts and methods from '''synthetic electrophysiology'''. Major interests are on in-depth biophysical mechanisms of ion channel functions, pursued by applying both biological and engineering principles onto biological entities (synthetic channel subunits & modulators etc.) and physical components (electrical & optical materials, devices, instruments, etc.) exogenously coupled with excitable membranes for the reconstitution of ion channels’ functionality & pathophysiology. We are particularly attracted by the amazing capabilities of ion channels in sensing exogenous stimuli of diverse modality, such as transmembrane potentials, ionic signals, mechanical forces and electromagnetic radiations. How exactly would ion channels sense, transduce and encode the stimuli (i.e., energy and information) at submolecular, molecular and cellular levels? Based on these core biophysics, we pursue mechanistic understanding, pathophysiological ramifications and bioengineering innovations, of '''transmembrane signalings''' via ion channels, especially those related to '''neural information processing''' (sensory functions and neural oscillations), and those crucial to '''neural plasticity''' (<math>Ca{_V}</math> channels and <math>Ca{^{2+}}</math> signaling).
 
The methodologies span from electrophysiology, biochemistry, molecular biology and optical imaging to biophysical modeling and engineering design & analysis.
One of the most important signaling pathways to convey information from external world into biological systems is by way of channels sitting across the membrane. Such channels: could be cued either by physical (e.g. voltage or photons) or by chemical signals (e.g. toxins or ions); could be either natural channels (e.g. ion channels conductive to Ca<sup>2+</sup> or K<sup>+</sup>) or engineered channels (e.g., nanopores by ultrasound). We mainly focus on fundamental mechanisms critical to channel complexes involved in transmembrane signaling, especially those related to sensory functions, such as vision, taste, hearing and other less-studied modalities. Representative work toward this direction refers to [http://www.nature.com/nature/journal/v463/n7283/full/nature08766.html '''Liu X.''' ''et. al.'' '''Nature''']. Meanwhile, we actively explore the potentials of novel methodologies developped or derived from our basic research, such as sonoporation, channel modulators, biomolecular sensors etc. [http://openwetware.org/wiki/User:Xiaodong_Liu relevant publications]
 
 
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== Lab News ==
 
'''Openings of Postdoc Position.'''
http://www.nature.com/naturejobs/science/jobs/191089-Postdoctoral-Fellow-Tsinghua-University
 
 
 
'''X-Lab (LIU Qing, XIE Xin and LIU Xiaodong) presented the poster:


CHARACTERIZATION OF QUANTITATIVE FRET SENSORS FOR FLUORESCENCE MOLECULAR TOMOGRAPHY'''
Author Block: Qing Liu, Xin Xie, Yi Zhang, Yanyan Xu, Yue Zhang, Xin Liu, Jing Bai, Xiaodong Liu.
Tsinghua University, Beijing, China.
during Biophysics Society Annual Meeting, March 2011 at Baltimore, MD, USA
== Updates ==
Course: Medical Physiology - Neurophysiology Section (April 30 - May 17, 2011) by Drs. LIU Guosong and LIU Xiaodong
http://openwetware.org/wiki/X:课程
2nd COLD SPRING HARBOR ASIA CONFERENCES - Membrane Proteins: Structure & Function May 16 - 20, 2011 (CSH)  Suzhou, China
http://www.csh-asia.org/membrane11.html
17th “International Symposium on Calcium-Binding Proteins and Calcium Function in Health and Disease” (CaBP17)  July 16-21 Beijing, China
http://www.ciccst.org.cn/CaBP/welcome.html
17th “International Biophysics Congress” (IAPUB)  Oct 30-Nov 3 Beijing, China
http://www.17ibc.org/
55th Annual Meeting of Biophysical Society March 5 - 9, 2011
http://www.biophysics.org/2011meeting
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Journal Club (Jointed with DU Lab and SONG Lab)
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== 2010 ==
<div style="clear: left; text-align: left; float: none">
[[Image:reprework_X.png|640px]]
Representative Work
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ZHANG Yue 8/12 FRET-based FMT
'''''


XU Yanyan 9/10 GPCR/Sensory Neuron


ZHAO Shan (from Du Lab) 9/25 Remotely Triggerable Drug Delivery Systems
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LIU Qing  10/15 reversible photoswitchable rsTagRFP for pcFRET
【2013.07.09】本实验室正在招募博士生、博士后（及技术员），欢迎对本实验室研究感兴趣、并希望在生物医学工程领域的科学研究上有所作为的候选人同本实验室PI [http://openwetware.org/wiki/User:Xiaodong_Liu Xiaodong LIU, Ph.D. (刘晓冬)]联系。另请参见[http://talent.sciencenet.cn/info.aspx?id=12706 科学网的招聘广告]。


YU Tao (from Song Lab) 10/22 Tetracycline-regulatable factors with distinct dimerization
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domains allow reversible growth inhibition by p16
 
TSE Yan Franco (XIE Xin)  10/29 Calcium Channels
 
NIU Pengxia (from DU Lab) 11/5 fuorescent structural DNA nanoballs functionalized with phsphate-linked nuceotide triphosphates
 
LI Xuesong (from SONG Lab) 11/19 global and local fmri signals driven by neurons defined optogenetically by type and writing
Claudia Wittkowske (from DU Lab) 11/26 "Glioblastoma stem-like cells give rise to tumour endothelium"
 
XUE Wenwen 12/10 bacteria magnetosome
 
YU Tao (from SONG Lab) 12/17 optical dimerization
 
XU Yanyan 12/24 Functional connectivity in the retina at the resolution of photoreceptors
 
== 2011 ==


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ZHAO Shan (from Du Lab) 1/7 Mimicking nature by codelivery of stimulant and inhibitor to create temporally stable and spatially restricted angiogenic zones
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LI Xuesong (from SONG Lab) 2/25 "Genetic dissection of an amygdala microcircuit that gates conditioned fear" and  "Encoding of conditioned fear in central amygdala inhibitory circuits"
[[X:News|X-LAB本科毕业设计获评2014年清华大学优秀毕业论文]]


LIU Nan 3/28 Salty Taste


[[X:News|X-LAB博士生在2014第十届全国钙信号会议(CSCS)上获评最佳墙报奖]]


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[[Image:X.png|thumb|left|400x400px|X-LAB. ]]
[[X:News|X-LAB本科毕业设计获得清华学堂班2014最佳科研成果奖]]


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---------------------------------------------------
[[X:News|X-LAB博士生获得清华大学短期出国访学基金]]
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<br>The following positions are currently available:


'''Postdoctoral Fellows'''


'''Technician'''
[[X:News|X-LAB博士后获评CLS优秀博士后基金]]


'''Ph.D. Students'''


'''Masters' Students'''
[[X:News|X-LAB博士后获评54期中国博士后基金]]


Please send email to [mailto:liuX.tsinghua@gmail.com Dr. Liu] if you are interested. Include your CV and a brief description of your career goals.


We also welcome '''undergraduate students''' (especially from major research universities in Beijing) to conduct research in our lab on thesis projects.
[[X:News|X-LAB本科生获评2013年优秀毕业论文]]


All above positions can start immediately.


[[X:News|X-LAB硕士生获得2011年国际生物物理年会Best Poster Award]]






[[X:BS20013|Attention: 刘晓冬研究组（X-LAB）本科生研究课题]]


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Revision as of 22:12, 10 July 2014


X-Laboratory

(跨膜信号研究组)

Principle Investigator: Xiaodong LIU, Ph.D. (刘晓冬)

Department of Biomedical Engineering, School of Medicine
IDG/McGovern Institute for Brain Research
School of Life Sciences
at Tsinghua University


Welcome to the X-Lab!


LAB DESCRIPTION

Our research has been in the field of ion channels, focusing on subthreshold or non-spiking behaviors and favoring concepts and methods from synthetic electrophysiology. Major interests are on in-depth biophysical mechanisms of ion channel functions, pursued by applying both biological and engineering principles onto biological entities (synthetic channel subunits & modulators etc.) and physical components (electrical & optical materials, devices, instruments, etc.) exogenously coupled with excitable membranes for the reconstitution of ion channels’ functionality & pathophysiology. We are particularly attracted by the amazing capabilities of ion channels in sensing exogenous stimuli of diverse modality, such as transmembrane potentials, ionic signals, mechanical forces and electromagnetic radiations. How exactly would ion channels sense, transduce and encode the stimuli (i.e., energy and information) at submolecular, molecular and cellular levels? Based on these core biophysics, we pursue mechanistic understanding, pathophysiological ramifications and bioengineering innovations, of transmembrane signalings via ion channels, especially those related to neural information processing (sensory functions and neural oscillations), and those crucial to neural plasticity ([math]\displaystyle{ Ca{_V} }[/math] channels and [math]\displaystyle{ Ca{^{2+}} }[/math] signaling). The methodologies span from electrophysiology, biochemistry, molecular biology and optical imaging to biophysical modeling and engineering design & analysis.


Representative Work



【2013.07.09】本实验室正在招募博士生、博士后（及技术员），欢迎对本实验室研究感兴趣、并希望在生物医学工程领域的科学研究上有所作为的候选人同本实验室PI Xiaodong LIU, Ph.D. (刘晓冬)联系。另请参见科学网的招聘广告。


X-LAB本科毕业设计获评2014年清华大学优秀毕业论文


X-LAB博士生在2014第十届全国钙信号会议(CSCS)上获评最佳墙报奖


X-LAB本科毕业设计获得清华学堂班2014最佳科研成果奖


X-LAB博士生获得清华大学短期出国访学基金


X-LAB博士后获评CLS优秀博士后基金


X-LAB博士后获评54期中国博士后基金


X-LAB本科生获评2013年优秀毕业论文


X-LAB硕士生获得2011年国际生物物理年会Best Poster Award


Attention: 刘晓冬研究组（X-LAB）本科生研究课题

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