X:Courses

Ion Channels of Excitable Membranes

可兴奋细胞膜之离子通道 【2014 Spring】 研究生专业课，2学分

Principles of Neural Science and Neural Engineering

生物医学工程系本科 神经工程模块 (2013 Fall)

神经科学与神经工程基础，3学分，三上

生物医学工程系本科 神经工程模块 (2012 Fall)

神经科学与神经工程基础，3学分，三上

课 程 教 学 大 纲

课程名称 神经科学与神经工程基础 课程负责人 刘晓冬、宋森

教学重点

面向生物医学工程系及相关工程系本科生，讲授神经系统的基础理论、基本原理及基本方法。课程重点在于神经科学和神经工程的核心原理；同时突出：把握前沿、定量分析及工程设计等特色。

课程主要内容教学：

（可列多级标题，如设有实验，还须注明各实验名称、实验目的及实验内容）

教材：Foundations of Cellular Neurophysiology (Johnson and Wu, Q42 FJ72); Essentials of Neural Science and Behavior (Eric Kandel, ISBN: 0838522459)

参考书：Ion Channels of Excitable Membrane (Bertil Hille); Neural Engineering (2008, CRC Press, Q42 FN497); Neuroscience (Dale Purves, ISBN 978-0878936977, 医学馆) ; Neural Engineering (ISBN: 0585444684, MIT Press); Principles of Neural Sciences (Eric Kandel, R338 FP95);

E-resource: Principles of Neural Sciences; Ion Channels of Excitable Membrane; Neuroscience

课程大纲 (Syllabus) 注：以下括号内为讲课次数（共16讲）

I. Introduction to Science and Engineering of Neural System 神经系统的科学及工程简介

Course Coverage and General Introduction (1) Liu, Song

(basic principles, quantitative bend, engineering emphasis) 课程概览及课程特色

II. Neural System (general overview and methodology):

Molecular, Cellular; (1) Liu

Circuit and System. (1) Song

纵览神经系统：分子、细胞、回路及系统

III. Neuronal Excitability 神经元兴奋性

Electrical Properties of Neural Membrane: 神经元细胞膜的电特性

Membrane and HH Analysis (1) Liu 细胞膜及H-H理论及分析

Ion Channels: Diversity and Physiology; Structure-Function: Single-Channel Analysis (2) Liu

离子通道：多样性及生理功能；结构及功能分析；单通道分析

Realistic Neuron, pre- and post-synaptic mechanisms (2) Song

神经元间的突触联接

Cable Equation (1) Song

神经系统电传导及电缆方程

Neural Stimulation (optical, electrical, etc.) (1) Song

神经系统的光电刺激

IV. Functions of Nervous System 神经系统的功能

Sensory and Motor (3) Liu

感觉及运动

Cognitive: Learning, Memory and Emotion. (3) Song

认知： 学习、记忆及情绪

考核成绩评定标准：考试（~50%）、平时作业（~25%）、课程报告（~25%）

2012 Spring-I

PTN清华进展和讨论生物学专题讨论之细胞膜离子通道基础专题模块 (2012 Spring)

上课时间：3/6；3/8；3/13；3/15 上午8:50-10:35 上课地点：清华 六教 6B308

Contact Info:
Xiaodong Liu (刘晓冬), Ph.D.
Professor of Biomedical Engineering and Life Sciences
Principle Investigator of X-Lab 
http://openwetware.org/wiki/X-Lab
School of Medicine
Tsinghua University
B-307 (office); B-229(Lab)
Voice: (86)10-62796733 (O); 

TA: 秦 毅（2011级PTN学生） 邮箱：ptnqyi@126.com 手机：18210604223

Lecture I （3/6) : Fundamentals of Ion Channels

a. Current Understanding: Permeation; Selectivity; Gating

b. Historical Retrospects

c. Molecular Physiology of Ion Channels (Molecular Biophysics & Pathophysiological Relevance)

Lecture II (3/8) : Quantitative Descriptions o of Ion Channel Behaviors

a. H-H, (see http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1392413/pdf/jphysiol01442-0106.pdf)

b. Single Channels (see http://openwetware.org/images/1/18/Paper_Neher_Lecture.pdf)

c. Simulations (see http://www.neuron.yale.edu/neuron/)

Lecture III (3/13): Frontiers of Ion Channels -I

a. Molecular Aspects

Paper A: http://www.nature.com/nature/journal/v451/n7180/full/nature06529.html

Paper B: http://www.nature.com/nature/journal/v463/n7283/full/nature08766.html

b. Comments, Insights and Beyond (for non-channel proteins, see http://bernstein.harvard.edu/papers/peter_science_1998.pdf)

Lecture IV (3/15): Frontiers of Ion Channels -II

a. Physiological Aspects

Paper C: http://www.nature.com/nature/journal/vaop/ncurrent/full/nature10812.html

Paper D: http://www.nature.com/nature/journal/v447/n7148/full/nature05865.html

b. Comments, Insights and Beyond (optogenetics, see http://en.wikipedia.org/wiki/Optogenetics)

c. Brief Summary

2012 Spring-II

医学药学实验班 生理学之感官神经生理 (2012 Spring)

2012.5.15 二 3 三教1209 sensory functions I

2012.5.18 五 2 三教1209 sensory functions II

Textbook: medical physiology chapter 31

2012 Fall-II

可兴奋细胞膜之离子通道

生物医学工程系 研究生选修课 (2012 Fall)