X:Research: Difference between revisions
From OpenWetWare
Jump to navigationJump to search
Xiaodong Liu (talk | contribs) No edit summary |
No edit summary |
||
| (8 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
[http://openwetware.org/wiki/X-Lab return to X-Laboratory] | [http://openwetware.org/wiki/X-Lab return to X-Laboratory] | ||
<div style="clear: left; text-align: left; float: none"> | <div style="clear: left; text-align: left; float: none"> | ||
</div> | </div> | ||
| Line 24: | Line 23: | ||
---- | ---- | ||
</div> | </div> | ||
|width=800px class="MainPageBG" style="border: 0px solid #CC3300; background-color: #ffffff"| | |width=800px class="MainPageBG" style="border: 0px solid #CC3300; background-color: #ffffff"| | ||
--> | --> | ||
<font face="Helvetica" size=4> | |||
1. Exemplar graduate project: molecular physiology of L-type Ca<sup>2+</sup> (Ca<sub>V</sub>1)channels | |||
</ | a. Ca<sub>V</sub>1-dependent signaling in excitable cells including neurons | ||
b. Design of specific modulators of Ca<sub>V</sub>1 subtypes | |||
2. Exemplar graduate project: fluorescence imaging and probes | |||
a. Design and characterizations of genetically-encoded probes/sensors for key biological signals | |||
b. Probe design and implementation of imaging systems/algorithms (GECI for Ca<sup>2+</sup> imaging; FRET 2-hybrid binding and sensors) | |||
<!-- To apply '''engineering principles''' onto both '''biological''' entities (synthetic ion channels & modulators etc.) and '''physical''' components (electrical & optical materials, devices, instruments, etc.) exogenously coupled with excitable membranes of the cell for the | |||
'''''re-constitution''''' of ion channels’ functions & pathophysiology. | |||
</font><br> | |||
<font face="Helvetica" size=3> | |||
</font> | |||
--> | |||
Latest revision as of 02:32, 8 March 2021
1. Exemplar graduate project: molecular physiology of L-type Ca2+ (CaV1)channels
a. CaV1-dependent signaling in excitable cells including neurons
b. Design of specific modulators of CaV1 subtypes
2. Exemplar graduate project: fluorescence imaging and probes
a. Design and characterizations of genetically-encoded probes/sensors for key biological signals
b. Probe design and implementation of imaging systems/algorithms (GECI for Ca2+ imaging; FRET 2-hybrid binding and sensors)
