X:Research

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[http://bme.med.tsinghua.edu.cn Department of Biomedical Engineering] at [http://www.tsinghua.edu.cn/eng/index.jsp Tsinghua University]
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[http://bme.med.tsinghua.edu.cn Department of Biomedical Engineering] at [http://www.med.tsinghua.edu.cn School of Medicine], [http://www.tsinghua.edu.cn/eng/index.jsp Tsinghua University]
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1. Sensory signaling via channel complex (''e.g.'', TRP/GPCR or Ca<SUB>V</SUB>/CaM).
 
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2. Novel modulators of Ca<SUP>2+</SUP> channels as tools to pursue molecular physiology.
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Our lab is broadly interested in transmembrane and sensory signaling based on channels, pursuing both biophysical mechanisms and bioengineering innovations.
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3. Design and application of genetically encoded (optical) sensors.
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One of the most important signaling pathways to convey information from external world into biological systems is by way of channels sitting across the membrane. Such channels: could be cued either by physical (e.g. voltage or photons) or by chemical signals (e.g. toxins or ions); could be either natural channels (e.g. ion channels conductive to Ca<sup>2+</sup> or K<sup>+</sup>) or engineered channels (e.g., nanopores by ultrasound). We mainly focus on fundamental mechanisms critical to channel complexes involved in transmembrane signaling, especially those related to sensory functions, such as vision, taste, hearing and other less-studied modalities. Representative work toward this direction refers to [http://www.nature.com/nature/journal/v463/n7283/full/nature08766.html '''Liu X.''' ''et. al.'' '''Nature''']. Meanwhile, we actively explore the potentials of novel methodologies developed or derived from our basic research, such as biomolecular sensors and actuators. [http://openwetware.org/wiki/User:Xiaodong_Liu#Publications relevant publications]
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4. Mechanisms and engineering of membrane nanoporation.<br>
 
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Journal Club
 
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ZHANG Yue 8/12 FRET-based FMT
 
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8/19??
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Revision as of 02:57, 9 July 2013



X-Laboratory
(Under Development)
Principle Investigator: Xiaodong Liu, Ph.D.

Department of Biomedical Engineering at School of Medicine, Tsinghua University



Research Projects


Our lab is broadly interested in transmembrane and sensory signaling based on channels, pursuing both biophysical mechanisms and bioengineering innovations.

One of the most important signaling pathways to convey information from external world into biological systems is by way of channels sitting across the membrane. Such channels: could be cued either by physical (e.g. voltage or photons) or by chemical signals (e.g. toxins or ions); could be either natural channels (e.g. ion channels conductive to Ca2+ or K+) or engineered channels (e.g., nanopores by ultrasound). We mainly focus on fundamental mechanisms critical to channel complexes involved in transmembrane signaling, especially those related to sensory functions, such as vision, taste, hearing and other less-studied modalities. Representative work toward this direction refers to Liu X. et. al. Nature. Meanwhile, we actively explore the potentials of novel methodologies developed or derived from our basic research, such as biomolecular sensors and actuators. relevant publications








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