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1. Exemplar graduate project: molecular physiology of L-type Ca<sup>2+</sup> (Ca<sub>V</sub>1)channels | |||
a. Excitation-transcription coupling by Ca<sub>V</sub>1 signaling in neurons | |||
b. Design of specific modulators of Ca<sub>V</sub>1 subtypes | |||
2. Exemplar graduate project: innovative quantitative Fluorescence Resonance Energy Transfer (FRET) imaging | |||
a. Design and characterizations of genetically-encoded probes/sensors for key biological signals | |||
b. Innovative platform of probe/imaging system/algorithm to expand 3<sup>3</sup>-FRET to microscopic and macroscopic imaging | |||
<!-- To apply '''engineering principles''' onto both '''biological''' entities (synthetic ion channels & modulators etc.) and '''physical''' components (electrical & optical materials, devices, instruments, etc.) exogenously coupled with excitable membranes of the cell for the | |||
'''''re-constitution''''' of ion channels’ functions & pathophysiology. | |||
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Revision as of 09:19, 26 July 2014
1. Exemplar graduate project: molecular physiology of L-type Ca2+ (CaV1)channels
a. Excitation-transcription coupling by CaV1 signaling in neurons
b. Design of specific modulators of CaV1 subtypes
2. Exemplar graduate project: innovative quantitative Fluorescence Resonance Energy Transfer (FRET) imaging
a. Design and characterizations of genetically-encoded probes/sensors for key biological signals
b. Innovative platform of probe/imaging system/algorithm to expand 33-FRET to microscopic and macroscopic imaging
