X:Research: Difference between revisions

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[http://openwetware.org/wiki/X-Lab return to X-Laboratory]
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'''X-Laboratory'''  </font> <br>
(Under Development) <br>
Principle Investigator: [http://openwetware.org/wiki/User:Xiaodong_Liu Xiaodong Liu, Ph.D.]
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[http://bme.med.tsinghua.edu.cn Department of Biomedical Engineering] at [http://www.med.tsinghua.edu.cn School of Medicine], [http://www.tsinghua.edu.cn/eng/index.jsp Tsinghua University]
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Research Projects
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1. Sensory signaling via channel complex (''e.g.'', TRP/GPCR or Ca<SUB>V</SUB>/CaM).


2. Novel modulators of Ca<SUP>2+</SUP> channels as tools to pursue molecular physiology.
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3. Design and application of genetically encoded (optical) sensors.
1. Exemplar graduate project: molecular physiology of L-type Ca<sup>2+</sup> (Ca<sub>V</sub>1)channels
[http://bme.tsinghua.edu.cn in collaboration with Dr. BAI Jing at Tsinghua University)
4. Mechanisms and engineering of membrane nanoporation.<br>
(in collaboration with Beijing Institute of Medical Devices)


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a. Excitation-transcription coupling by Ca<sub>V</sub>1 signaling in neurons


b. Design of specific modulators of Ca<sub>V</sub>1 subtypes


2. Exemplar graduate project: innovative quantitative Fluorescence Resonance Energy Transfer (FRET) imaging


a. Design and characterizations of genetically-encoded probes/sensors for key biological signals


b. Innovative platform of probe/imaging system/algorithm to expand 3<sup>3</sup>-FRET to microscopic and macroscopic imaging


 
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'''''re-constitution''''' of ion channels’ functions & pathophysiology.
 
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Revision as of 09:19, 26 July 2014

return to X-Laboratory


1. Exemplar graduate project: molecular physiology of L-type Ca2+ (CaV1)channels

a. Excitation-transcription coupling by CaV1 signaling in neurons

b. Design of specific modulators of CaV1 subtypes

2. Exemplar graduate project: innovative quantitative Fluorescence Resonance Energy Transfer (FRET) imaging

a. Design and characterizations of genetically-encoded probes/sensors for key biological signals

b. Innovative platform of probe/imaging system/algorithm to expand 33-FRET to microscopic and macroscopic imaging


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