X:Research: Difference between revisions

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[http://openwetware.org/wiki/X-Lab return to X-Laboratory]
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'''X-Laboratory'''  </font> <br>
(Under Development) <br>
Principle Investigator: [http://openwetware.org/wiki/User:Xiaodong_Liu Xiaodong Liu, Ph.D.]
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[http://bme.med.tsinghua.edu.cn Department of Biomedical Engineering] at [http://www.tsinghua.edu.cn/eng/index.jsp Tsinghua University]
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Research Projects
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1. Exemplar graduate project: molecular physiology of L-type Ca<sup>2+</sup> (Ca<sub>V</sub>1)channels


1. Sensory signaling via channel complex (''e.g.'', TRP/GPCR or Ca<SUB>V</SUB>/CaM).
a. Ca<sub>V</sub>1-dependent signaling in excitable cells including neurons


2. Novel modulators of Ca<SUP>2+</SUP> channels as tools to pursue molecular physiology.
b. Design of specific modulators of Ca<sub>V</sub>1 subtypes


3. Design and application of genetically encoded sensors.
2. Exemplar graduate project: fluorescence imaging and probes


4. Mechanisms and engineering of membrane nanoporation.
a. Design and characterizations of genetically-encoded probes/sensors for key biological signals


b. Probe design and implementation of imaging systems/algorithms (GECI for Ca<sup>2+</sup> imaging; FRET 2-hybrid binding and sensors)


<!-- To apply '''engineering principles''' onto both '''biological''' entities (synthetic ion channels & modulators etc.) and '''physical''' components (electrical & optical materials, devices, instruments, etc.) exogenously coupled with excitable membranes of the cell for the
'''''re-constitution''''' of ion channels’ functions & pathophysiology.
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Latest revision as of 02:32, 8 March 2021

return to X-Laboratory


1. Exemplar graduate project: molecular physiology of L-type Ca2+ (CaV1)channels

a. CaV1-dependent signaling in excitable cells including neurons

b. Design of specific modulators of CaV1 subtypes

2. Exemplar graduate project: fluorescence imaging and probes

a. Design and characterizations of genetically-encoded probes/sensors for key biological signals

b. Probe design and implementation of imaging systems/algorithms (GECI for Ca2+ imaging; FRET 2-hybrid binding and sensors)


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