X:Research: Difference between revisions
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[http://openwetware.org/wiki/X-Lab return to X-Laboratory] | |||
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1. Exemplar graduate project: molecular physiology of L-type Ca<sup>2+</sup> (Ca<sub>V</sub>1)channels | |||
a. Ca<sub>V</sub>1-dependent signaling in excitable cells including neurons | |||
b. Design of specific modulators of Ca<sub>V</sub>1 subtypes | |||
2. Exemplar graduate project: fluorescence imaging and probes | |||
a. Design and characterizations of genetically-encoded probes/sensors for key biological signals | |||
b. Probe design and implementation of imaging systems/algorithms (GECI for Ca<sup>2+</sup> imaging; FRET 2-hybrid binding and sensors) | |||
<!-- To apply '''engineering principles''' onto both '''biological''' entities (synthetic ion channels & modulators etc.) and '''physical''' components (electrical & optical materials, devices, instruments, etc.) exogenously coupled with excitable membranes of the cell for the | |||
'''''re-constitution''''' of ion channels’ functions & pathophysiology. | |||
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Latest revision as of 02:32, 8 March 2021
1. Exemplar graduate project: molecular physiology of L-type Ca2+ (CaV1)channels
a. CaV1-dependent signaling in excitable cells including neurons
b. Design of specific modulators of CaV1 subtypes
2. Exemplar graduate project: fluorescence imaging and probes
a. Design and characterizations of genetically-encoded probes/sensors for key biological signals
b. Probe design and implementation of imaging systems/algorithms (GECI for Ca2+ imaging; FRET 2-hybrid binding and sensors)
