X:Research: Difference between revisions

From OpenWetWare
Jump to navigationJump to search
No edit summary
No edit summary
 
(15 intermediate revisions by 2 users not shown)
Line 1: Line 1:
[http://openwetware.org/wiki/X-Lab return to X-Laboratory]
<div style="clear: left; text-align: left; float: none">
</div>


__NOTOC__
<!--  
<br>
<center>
<font face="Helvetica" size=6 color=#339900>
'''X-Laboratory'''  </font> <br>
(Under Development) <br>
Principle Investigator: [http://openwetware.org/wiki/User:Xiaodong_Liu Xiaodong Liu, Ph.D.]
<br>
 
[http://bme.med.tsinghua.edu.cn Department of Biomedical Engineering] at [http://www.med.tsinghua.edu.cn School of Medicine], [http://www.tsinghua.edu.cn/eng/index.jsp Tsinghua University]
</center>
----
----
 
{| cellspacing="2"  
{| cellspacing="2"  
|- valign="top"
|- valign="top"
Line 35: Line 25:


|width=800px class="MainPageBG" style="border: 0px solid #CC3300; background-color: #ffffff"|
|width=800px class="MainPageBG" style="border: 0px solid #CC3300; background-color: #ffffff"|
<font face="Helvetica" size=4>
Research Projects
</font><br>


<font face="Helvetica" size=3>
-->




Our lab is broadly interested in transmembrane and sensory signaling based on channels, pursuing both biophysical mechanisms and bioengineering innovations.
<font face="Helvetica" size=4>


One of the most important signaling pathways to convey information from external world into biological systems is by way of channels sitting across the membrane. Such channels: could be cued either by physical (e.g. voltage or photons) or by chemical signals (e.g. toxins or ions); could be either natural channels (e.g. ion channels conductive to Ca<sup>2+</sup> or K<sup>+</sup>) or engineered channels (e.g., nanopores by ultrasound). We mainly focus on fundamental mechanisms critical to channel complexes involved in transmembrane signaling, especially those related to sensory functions, such as vision, taste, hearing and other less-studied modalities. Representative work toward this direction refers to [http://www.nature.com/nature/journal/v463/n7283/full/nature08766.html '''Liu X.''' ''et. al.'' '''Nature''']. Meanwhile, we actively explore the potentials of novel methodologies developed or derived from our basic research, such as biomolecular sensors and actuators. [http://openwetware.org/wiki/User:Xiaodong_Liu#Publications relevant publications]
1. Exemplar graduate project: molecular physiology of L-type Ca<sup>2+</sup> (Ca<sub>V</sub>1)channels


a. Ca<sub>V</sub>1-dependent signaling in excitable cells including neurons


b. Design of specific modulators of Ca<sub>V</sub>1 subtypes


</font>
2. Exemplar graduate project: fluorescence imaging and probes


a. Design and characterizations of genetically-encoded probes/sensors for key biological signals


b. Probe design and implementation of imaging systems/algorithms (GECI for Ca<sup>2+</sup> imaging; FRET 2-hybrid binding and sensors)


 
<!-- To apply '''engineering principles''' onto both '''biological''' entities (synthetic ion channels & modulators etc.) and '''physical''' components (electrical & optical materials, devices, instruments, etc.) exogenously coupled with excitable membranes of the cell for the
 
'''''re-constitution''''' of ion channels’ functions & pathophysiology.
 
</font><br>
 
<font face="Helvetica" size=3>
 
</font>
 
-->
 
 
 
 
|}

Latest revision as of 02:32, 8 March 2021

return to X-Laboratory


1. Exemplar graduate project: molecular physiology of L-type Ca2+ (CaV1)channels

a. CaV1-dependent signaling in excitable cells including neurons

b. Design of specific modulators of CaV1 subtypes

2. Exemplar graduate project: fluorescence imaging and probes

a. Design and characterizations of genetically-encoded probes/sensors for key biological signals

b. Probe design and implementation of imaging systems/algorithms (GECI for Ca2+ imaging; FRET 2-hybrid binding and sensors)


Retrieved from "https://openwetware.org/mediawiki/index.php?title=X:Research&oldid=1096570"