Xiaoqing Lin
B.S.
Graduate student
Web Master
Unlike solid tumors, leukemia can not be removed by surgery. Therefore, understanding how leukemia initiate and progress on the molecular level is particularly important for developing treatments. I study Myeloproliferative Neoplasms (MPNs), which is a type of blood malignancy caused by overproliferation of blood cells. For my thesis work, I compared the genetic profiles of MPN patients to healthy controls, identified several genes that are misregulated in patients, and studied their contribution to the development of MPNs. In the past five years, I worked with human and mouse bone marrow samples, performed bone marrow transplantation on mice, and acquired a wide range of bench research skills in molecular and cell biology. NFIB in Polycythemia Vera. It's known that 90% of the P. Vera patients have a mutation in JAK2 protein, in which the V617 is substituted with a phenylalanine. It has been shown by a former graduate student in the lab that besides JAK2V617, NFIB is significantly upregulated in P. Vera patients. In addition, NFIB is located in close proximity to the JAK2 gene on the 9th chromosome. Therefore, the goal of my project is to identify the role of NFIB in P. Vera, as well as its correlation with JAK2V617F.
I majored in molecular biology at Purdue University, and graduated with honors in 2006. Besides research, I like drawing, yoga, art, exploring new hot spots in Chicago, and a whole bunch of other stuff. You can msg/email/facebook me if you have any questions about the lab or the lab website.
Experience
Dr. Jonathan Licht’s lab, Lurie Cancer Center, Northwestern University, Chicago, IL
03/07 - present
Graduate Student
• Lead investigations on the pathogenesis of MPN using human specimens and mouse models
Graduate level tumor cell biology, Northwestern University, Chicago, IL
03/08 – 06/08
Teaching assistant
• Teaching miRNA and cancer section of the class and provide instructional support in classroom
Dr. Jue Chen’s lab, Purdue University Structural Group, West Lafayette, IN
09/03 – 05/06
Undergraduate research assistant
• Expressing and purifying MalK protein in E. coli and nucleotide binding studies
Purdue University Structural Biology Group, West Lafayette, IN
05/05 – 09/05
Intern
• Independent investigation on MalK E159Q mutant purification and nucleotide binding studies in E.coli
Purdue University Structural Biology Group, West Lafayette, IN
05/04 – 09/04
Intern
• Cloning of West Nile, Yellow Fever, and Japanese Encephalitis virus structural genes
Dr. Charles Tseng’s lab, Purdue University Calumet, Hammond, IN
08/02 – 09/03
Undergraduate researcher assistant
• Assisted establishing a DNA fingerprint database to trace the source of E. coli from environmental samples
Awards
Malkin Scholar 2009
American Hematology Association Award 2008, 2009
Merck Award for Excellent Student in Biology 2006
Purdue University Undergraduate with Research Honors Presentation and Poster 2006
Dean’s List Student 2002 – 2006
National Dean’s List Student 2002 – 2005
Howard Hughes Internship 2005
Dr. Melven J. Glimcher Fund for Science Scholarship 2004
Purdue Cancer Center Summer Research Grant 2004
Email: x-lin@northwestern.edu
My graduate program: IGP
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