Xu lab:Publications

Laboratory of Nanomedicine and Biomaterials

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PUBLICATIONS Peer-reviewed Articles 49. Hu, X., Wang, M., Shi, S., Raja, M., Gupta, G., Chen, H., and Xu, P.* Polymer/copper nanocomplex-induced lysosomal cell death promotes tumor lymphocyte infiltration and synergizes anti-PD-L1 immunotherapy for triple-negative breast cancer. Biomaterials Science (2023), 11, 5641-5652. [1] 48. Liu, H. and Xu, P.* Strategies to overcome/penetrate the BBB for systemic nanoparticle delivery to the brain/brain tumor. Advanced Drug Delivery Reviews (2022), 191, 114619. [2] 47. Mithil Soni, Ozge Saatci, Gourab Gupta, Yogin Patel, Manikanda Raja Keerthi Raja, Jie Li, Xinfeng Liu, Peisheng Xu, Hongjun Wang, Daping Fan, Ozgur Sahin, Hexin Chen * miR-489 confines uncontrolled estrogen signaling through a negative feedback mechanism and regulates tamoxifen resistance in breast cancer. International Journal of Molecular Sciences (2022), 23(15), 8086. [3] 46. Liu, H., Wang, M., Shi, S., Hu, X., and Xu, P.* A therapeutic sheep in metastatic wolf’s clothing: Trojan horse approach for cancer brain metastases treatment. Nano-Micro Letters (2022), 14, 114. [4]. 45. Sui, B., Chen, C., Shi, S., Wang, M., and Xu, P.* Esterase-activatable and GSH-responsive Triptolide Nano-prodrug for the Eradication of Pancreatic Cancer. Advanced NanoBiomed Research (2021), 1(11), 2100040 [5] 44. Yang, L, Wu, C, Tucker, L, Xu, P., Zhang, Q. Photobiomodulation Therapy Attenuates Anxious-Depressive-Like Behavior in Alzheimer Rat. Journal of Alzheimer's Disease 2021, [6]. 43. Sui, B., Wang, M., Chen, C., Zhang, Q., Zhang, J., Fan, D., and Xu, P.* Nanogel-facilitated Protein Intracellular Specific Degradation through Trim-Away. Advanced Functional Materials (2021),31(30), 2010556 [7] 42. Liu, H., Wang, J., Wang, M., Wang, Y., Shi, S., Hu, X., Zhang, Q., Fan, D., and Xu, P.* Biomimetic Nanomedicine Coupled with Neoadjuvant Chemotherapy to Suppress Breast Cancer Metastasis via Tumor Microenvironment Remodeling. Advanced Functional Materials (2021), 31(25), 2100262 [8] (Inside back cover) [9] 41. Zhang, Z., Wang, X., Wei, X., Zheng, S., Lenhart, B., Xu, P., Li, J., Pan, J., Albrecht, H., Liu, C.* Multiplex Quantitative Detection of SARS-CoV-2 Specific IgG and IgM Antibodies based on DNA-assisted Nanopore Sensing. Biosensors and Bioelectronics 2021, 181: 113134. [10] 40. Cheng, B. and Xu, P.* Redox-Sensitive Nanocomplex for Targeted Delivery of Melittin. Toxins (2020), 12, 582. [11] 39. Cheng, C., Sui, B., Wang, M., Hu, X., Shi, S., and Xu, P.* Carrier-free nano-assembly of curcumin-erlotinib conjugate for cancer targeted therapy. Advanced Healthcare Materials (2020),9(19),e2001128. [12] 38. Liu, H., Wang, M., Hu, X., Shi, S., and Xu, P.* Enhanced photothermal therapy through the in-situ activation of a temperature and redox dual-sensitive nano-reservoir of triptolide. Small (2020), 16 (38), 2003398. [13] 37. Liu, Q., Hodge, J., Wang, J., Wang, Y., Wang, L., Singh, U., Li, Y., Yao, Y., Wang, D., Ai, W., Nagarkatti, P., Chen, H., Xu, P., Murphy, E.A., and Fan, D. Emodin reduces breast cancer lung metastasis by suppressing macrophage-induced breast cancer cell epithelial mesenchymal transition and cancer stem cell formation. Theranostics (2020), 10(18):8365-8381.[14] 36. Sui, B., Cheng, C., Wang, M., Hopkins, E., and Xu, P.* Hetero-targeted nano-cocktail with traceless linkers for eradicating cancer. Advanced Functional Materials (2019), 29 (50), 1906433. [15] (Cover Page)[16] 35. He, H., Nieminen, A-L, and Xu, P.* Bioactivatable Self-quenched Nanogel for Targeted Photodynamic Therapy. Biomaterials Science (2019), 7, 5143-5149.[17] 34. Sui, B., Cheng, C., and Xu, P.* Pyridyl Disulfide Functionalized Polymers as Nanotherapeutic Platforms. Advanced Therapeutics. (2019), 2, 1900062. [18] 33. Liu, H. and Xu, P.* Smart Mesoporous Silica Nanoparticles for Protein Delivery. Nanomaterials (2019), 9, 511. 32. Cheng, B., Gao, F., Maissy, E., and Xu, P.* Repurposing suramin for the treatment of breast cancer lung metastasis with glycol chitosan based nanoparticles. Acta Biomaterialia (2019), 84, 378–390.[19] 31. Mithil Soni, Yogin Patel, Eleni Markoutsa, Chunfa Jie, Shou Liu, Xu, P and Hexin Chen* miR-489 regulates autophagy, cell viability and chemo-resistance in breast cancer cells. Molecular Cancer Research (2018),16(9):1348-1360. (05/01/18) 30. He, H., Markoutsa, E., Li, J., and Xu, P.* Repurposing Disulfiram for Cancer Therapy via Targeted Nanotechnology through Enhanced Tumor Mass Penetration and Disassembly. Acta Biomaterialia (2018), 68, 113-124. [20] Reported by MD linX [21]. 29. He, H., Markoutsa, E., Zhan, Y., Zhang, J., and Xu, P.* Mussel-Inspired PLGA/polydopamine Core-shell Nanoparticle for Light Induced Cancer Thermochemotherapy. Acta Biomaterialia(2017), 59, 181–191.[22]. 28. Markoutsa, E. and Xu, P.* Redox Potential-Sensitive N‑Acetyl Cysteine-Prodrug Nanoparticles Inhibit the Activation of Microglia and Improve Neuronal Survival. Molecular Pharmaceutics (2017), 14 (5), 1591–1600 [23]. 27. Patel, Y., Shah, N., Lee, JS., Markoutsa, E., Jie, C., Liu, S., Botbyl, R., Reisman, D., Xu, P., and Chen, H. A novel double-negative feedback loop between miR-489 and the HER2-SHP2-MAPK signaling axis regulates breast cancer cell proliferation and tumor growth.Oncotarget (2016) 7, 18295-18308 [24] 26. He, H., Altomare, D., Ozer, U., Xu, H., Creek, K., Chen, H., and Xu, P.* Cancer cell selective-killing polymer/copper combination. Biomaterials Science (2016), 4, 115 - 120. (Back Cover) [25]. 25. Cheng, B., He, H., Huang, T., Berr, S., He, J., Fan D., Zhang, J., and Xu, P.* Gold Nanosphere Gated Mesoporous Silica Nanoparticle Responsive to NIR Light and Redox Potential as a Theranostic Platform for Cancer Therapy. Journal of Biomedical Nanotechnology (2016), 12, 435-449.[26] 24. Cheng, B., Thapa, B., K.C., R., and Xu, P.* Dual secured nano-melittin for safe and effective eradicating cancer cells. Journal of Materials Chemistry B (2015), 3 (1), 25 - 29. [27]. 23. He, H., Cattran, A., Nguyen, T., Nieminen, A., and Xu, P.* Triple-responsive Expansile Nanogel for Tumor and Mitochondria Targeted Photosensitizer Delivery. Biomaterials, (2014), 35, 9546–9553. [28] 22. K.C., R., Chandrashekaran, V., Cheng, B., Chen, H., Peña, M., Zhang, J., Montgomery, J., Xu, P.* Redox Potential Ultrasensitive Nanoparticle for Targeted Camptothecin Delivery to HER2-Positive Cancer Cells. Molecular Pharmaceutics, (2014), 11, 1897−1905. [29] 21. Chen, Y., Wu, C., Yeo, Y., Xu, P., Lin, T. A DNA prime-protein boost vaccination strategy targeting turkey coronavirus spike protein fragment containing neutralizing epitope against infectious challenge. Veterinary Immunology and Immunopathology (2013), 152: 359-369. [30] 20. Cao, Z., Chen, F., Bao, N., He, H., Xu, P., Jana, S., Jung, S., Lian, H., Lu, C. Droplet Sorting Based on the Number of Encapsulated Particles Using a Solenoid Valve. Lab on a Chip, (2013),13, 171-178. [31] 19. K.C. R., Xu P.*, Multicompartment Intracellular Self-expanding Nanogel for Targeted Delivery of Drug Cocktail. Advanced Materials, (2012),24(48): 6479-6483. [32] Highlighted as a key scientific article in Global Medical Discovery [33] Reported by Science Daily [34] Drug Discovery Today [35] Azonano [36] Genesis Nanotech [37] Polymer solutions [38], and Newswise [39] 18. K.C. R., Thapa B., Xu P.*, pH and redox dual responsive nanoparticle for nuclear targeted drug delivery. Molecular Pharmaceutics, (2012) 9 (9), 2719-2729. (One of the journal’s Top 10 most read articles during July-September 2012) [40] 17. K.C. R., Thapa B., Xu P.*, Design of serum compatible tetrary complexes for gene delivery. Macromol. Biosci. (2012), 12, 637–646. (Cover page) [41] PoSC_cover_ftp.pdf. 16. Chen F, Zhan Y, Geng T, Lian H, Xu P, Lu C. Chemical Transfection of Cells in Picoliter Aqueous Droplets in Fluorocarbon Oil. Anal Chem. (2011), 83 (22), 8816–8820. [42] 15. Shen, Y., Zhou, Z., Sui, M., Tang, J., Xu, P., Van Kirk, E.A., Murdoch, W.J., Fan, M., and Radosz, M. Charge-reversal polyamidoamine dendrimer for cascade nuclear drug delivery. Nanomedicine, (2010), 5(8), 1205-1217. [43] 14. Xu, P., Bajaj, G., Shugg, T., Van Alstine, W., and Yeo, Y.: Zwitterionic chitosan derivatives for pH-sensitive stealth coating. Biomacromolecules. (2010), 11(9), 2352-2358. [44] 13. Ma H., Jones K.R., Guo R., Xu, P., Shen Y., and Ren J., Cisplatin Compromises Myocardial Contractile Function and Mitochondrial Ultrastructure: Role of Endoplasmic Reticulum Stress. Clin Exp Pharmacol Physiol. (2010), 37(4), 460-465. 12. Xu, P., Quick G. and Yeo, Y., Gene delivery through the use of a hyaluronate-associated intracellularly degradable crosslinked polyethyleneimine. Biomaterials. (2009), 30 (29):5834-43. 11. Xu, P., Gullotti, E., Tong, L., Highley, C.B., Errabelli, D.R., Hasan, T., Cheng, J., Kohane, D.S., and Yeo, Y., Intracellular drug delivery by poly(lactic-co-glycolic acid) nanoparticles, revisited. Molecular Pharmaceutics (2009), 6(1), 190-201. 10. Yang, Y., Bajaj, N., Xu, P., Ohn, K., Tsifansky, M., and Yeo, Y. Development of highly porous large PLGA microparticles for sustained local drug delivery to the lung. Biomaterials (2009), 30(10), 1947-53. 9. Xu, P., Li, S., Li, Q., Van Kirk, E.A, Ren, J., Murdoch, W.J., Zhang, Z., Radosz, M., and Shen, Y. Virion-mimicking nanocapsules from pH-controlled hierarchical self-assembly for gene delivery. Angew Chem Int Ed. (2008), 47(7), 1260-1264. 8. Shen, Y., Zhan Y., Tang J., Xu P., Johnson P.A., Radosz M., Van Kirk E.A., Murdoch, W.J. Multifunctioning pH-responsive nanoparticles from hierarchical self-assembly of polymer brush for cancer drug delivery. AIChE Journal (2008), 54 (11), 2979-2989. 7. Turdi, S., Xu, P., Li, Q., Kerram, P., Shen, Y., and Ren, J., Amidization of doxorubicin alleviates doxorubicininduced cardiomyopathy. Toxicol. Lett. (2008), 178(3), 197-201 6. Xu, P., Van, Kirk E.A., Zhan, Y., Murdoch, W.J., Radosz, M., and Shen, Y., Targeted charge-reversal nanoparticles for nuclear drug delivery. Angew Chem Int Ed. (2007), 46(26), 4999-5002. 5. Jin, W., Xu, P., Zhan, Y., Shen, Y., Van Kirk, E.A., Alexander, B., Murdoch, W.J., Liu, L., and Issak, D.D., Degradable cisplatin-releasing core-shell nanogels from zwitterionic poly(beta-aminoester)-graft-PEG for cancer chemotherapy. Drug Delivery. (2007), 14(5), 279-86. 4. Xu, P., Li, S., Li, Q., Ren, J., Van Kirk, E.A., Murdoch, W.J., Radosz, M., and Shen, Y., Biodegradable cationic polyester as an efficient carrier for gene delivery to neonatal cardiomyocytes. Biotechnology & Bioengineering (2006), 95(5), 893-903. 3. Xu, P., Van Kirk, Edward E.A., Murdoch, W.J., Zhan, Y., Isaak, Dale D., Radosz, M., and Shen, Y., Anticancer efficacies of cisplatin-releasing pH-responsive nanoparticles. Biomacromolecules (2006), 7(3), 829-835. 2. Xu, P., Van Kirk, E.A., Li, S., Murdoch, W.J., Ren, J., Hussain, M.D., Radosz, M., and Shen, Y., Highly stable core-surface-crosslinked nanoparticles as cisplatin carriers for cancer chemotherapy. Colloids and Surfaces, B: Biointerfaces (2006), 48(1), 50-57. 1. Xu, P., Tang, H., Li, S., Ren, J., Van Kirk, E.A., Murdoch, W.J., Radosz, M., and Shen, Y., Enhanced stability of core-surface cross-linked micelles fabricated from amphiphilic brush copolymers. Biomacromolecules (2004), 5(5), 1736-1744. Patents 18. Xu, P., Sui, B. The fabrication and application of Hetero-Targeted Nano-Cocktail with Traceless Linkers. US Utility patent No. 11,478,493. (10/25/2022). 17. Xu, P., Cheng, B., and He, H. Preparations of Gold/Mesoporous Silica Hybrid Nanoparticle and Applications. US Utility patent No. 11,007,207. (05/18/2021). 16. Xu, P. The Fabrication of a Suramin-Loaded Nanoparticle and Its Application. US Utility patent No. 11,000,482. (05/11/2021). 15. Xu, P., Nanoparticles for Brain Targeted Drug Delivery. US Utility patent No. 10,842,755. (11/24/2020). 14. Xu, P., and He, H. Preparations of Poly(lactic-co-glycolic acid)/Polydopamine Core/Shell Hybrid Nanoparticle for Photothermal Applications. US Utility patent No. 10,835,605. (11/17/2020). 13. Xu, P., and K.C., R. Tetrary gene delivery system for gene therapy and methods of its use. US Utility patent No. 9,168,230. (08/14/2018). 12. Yeo, Y., Bajaj, G., Xu, P., Cho, E., and Liu, K. Chitosan derivatives for inactivation of endotoxins and surface protection of nanoparticles. US Utility patent application No. 15/345,870, issued patent No. 9,962,401. (05/08/2018). 11. Xu, P., and He, H. Polymeric prodrug of disulfiram and application thereof. US Utility patent application No. 14,962,426, issued patent number is 9,861,704. 10. Xu, P., and He, H. Polymer/copper combination for cancer targeted therapy. US Utility Patent application No. 14,887,373, issued patent number is 9,822,202. (11/01/2017). 9. Yeo, Y., Bajaj, G., Xu, P., Cho, E., and Liu, K. Chitosan derivatives for inactivation of endotoxins and surface protection of nanoparticles. US Utility patent 9,517,246. (2016) 8. Yeo, Y., Bajaj, G., Xu, P., Cho, E., and Liu, K. Chitosan derivatives for inactivation of endotoxins and surface protection of nanoparticles. US Utility patent application No. 13/628,991, issued patent No. 9,393,262. (07/19/2016). 7. Xu, P., and He, H. Preparation of Triple Responsive Nanogel System and its Application. US Utility patent application No.14/330,336, issued patent No. 9,283,281. (02/24/2016). 6. Xu, P., and K.C., R. Tetrary gene delivery system for gene therapy and methods of its use. US Utility patent application No.13/477,701, issued patent No. 9,168,230. (10/27/2015). 5. Xu, P., and K.C., B. Preparation of nanogel cocktail and its application. US Utility patent application No. 13/929,981, issued patent No. 9,149,535. (10/06/2015). 4. Shen, Y., and Xu, P., Charge reversible polymers. PCT/US2007/015447. US Utility patent application No. 12/242,191, issued patent No. 9,145,472. (09/29/2015). 3. Radosz M., Xu, P., and Shen, Y., Nanoparticles for cytoplasmic drug delivery to cancer cells. US Utility Patent application No. 11/662,514, issued patent No. 8,945,629. (02/03/2015) 2. Xu, P., Thapa, B., and Cheng, B. Dual secured therapeutic peptide delivery system for cancer therapy. US Utility Patent application No. 13/610,109, issued patent No. 8,809,277. (08/19/2014) 1. Shen, Y., and Xu, P., Targeted charge-reversal nanoparticles for nuclear drug delivery. PCT/US2007/008146. Book Chapter 3. Cheng, B., and Xu, P.* Fabrication of Photothermal Stable Gold Nanosphere/Mesoporous Silica Hybrid Nanoparticle Responsive to Near-Infrared Light. Reema Zeineldin. (eds). Cancer Nanotechnology. 2017, Volume 1530 of the series Methods in Molecular Biology. pp 117-123, Springer New York. DOI: 10.1007/978-1-4939-6646-2_7. 2. He, H., Cheng, B., and Xu, P.* Natural Cationic Polymers for Gene Delivery. In Merkel, O.M. and Amiji, M.M. (eds). Advances and Challenges in the Delivery of Nucleic Acid Therapeutics. 2015, Volume (1), pp 82-94, Future Science Ltd, London, UK. DOI: 10.4155/fseb2013.13.132. 1. He, H., K.C., R., Xu, P.* Fabrication of cRGD-Conjugated Dual-Responsive Micelles to Target αvβ5 Integrin-Overexpressed Cancer. Methods in Pharmacology and Toxicology, 2015, pp1-16, Humana Press. DOI: 10.1007/7653_2015_42. ABSTRACTS AND PRESENTATIONS 16. Xu. P., Yeo, Y., Polyanion-Coated Intracellularly Degradable Nanoparticles as a Safe and Efficient Gene Delivery System. 35th Annual Meeting of the Controlled Release Society, New York, NY, (2008) 15. Yeo, Y., Yang, Y., Bajaj, N., Xu, P., Development of Highly Porous PLGA Microparticles for Sustained Local Drug Delivery to the Lung. 35th Annual Meeting of the Controlled Release Society, New York, NY, (2008) 14. Ma, H., Xu, P., Shen, Y., Ren, J., Cisplatin compromises the ultrastructure of mitochondria and mechanical func tion of cardiomyocytes. 2008 NISBRE, Washington DC, (2008) 13. Xu, P., Van Kirk, E.A., Zhan, Y., Murdoch, W.J., Radosz, M., and Shen, Y., Targeted charge-reversal nanoparticles for nuclear drug delivery. 34th Annual Meeting of the Controlled Release Society, Long Beach, California, (2007) 12. Xu, P., Zhan, Y., Van Kirk, E.A., Murdoch, W.J., and Shen, Y., Charge-reversal PAMAM dendrimer. 34th Annual Meeting of the Controlled Release Society, Long Beach, California, (2007). 11. Xu, P., Zhan, Y., Li, S., Van Kirk, E.A., Ren, J., Murdoch, W.J., Radosz, M., and Shen, Y., Artificial virion nanocapsules for gene delivery. 34th Annual Meeting of the Controlled Release Society, Long Beach, California, (2007). 10. Xu, P., Zhan, Y., Li, S., Van Kirk, E.A., Ren, J., Murdoch, W.J., Radosz, M., and Shen, Y., Layered nanoparticles for gene delivery. 232nd ACS National Meeting, San Francisco (2006). 9. Xu, P., Li, S., Li, Q., Zhan, Y., Ren, J., Radosz, M., and Shen, Y., Polymeric artificial virus for gene delivery. 231st ACS National Meeting, Atlanta (2006). 8. Zhan, Y., Van Kirk, E.A., Xu, P., Murdoch, W.J., Radosz, M., and Shen, Y., pH-responsive three layer onion-structured nanoparticles for drug delivery. 231st ACS National Meeting, Atlanta (2006). 7.Xu P., Li S., Li Q., Ren J., Shen Y., and Radosz M., Modified polymers as safe and efficient gene delivery carriers. 230th ACS National Meeting, Washington (2005). 6.Shen, Y., Xu, P., Li, S., Li, Q., Ren, J., Van Kirk, E.A., Murdoch, W.J., and Radosz, M., Biodegradable cationic polymers as efficient gene delivery carriers. 229th ACS National Meeting, San Diego (2005). 5.Xu, P., Tang, H., Li, S., Ren, J., Van Kirk, E.A., Murdoch, W.J., Radosz, M., and Shen, Y., Highly stable core-surface-crosslinked micelles as drug carriers for cancer chemotherapy. AIChE Annual Meeting, Austin (2004) 4.Xu, P., Van Kirk, E.A., Li, S., Ren, J., Murdoch, W.J., Radosz, M., and Shen, Y. Enhanced anticancer activity of core-surface-crosslinked nanoparticles. 228th ACS National Meeting, Philadelphia (2004). 3.Xu, P., Radosz, M., and Shen, Y., Pseudo "living" free radical copolymerization of methacrylic macromonomers. 228th ACS National Meeting, Philadelphia (2004). 2.Yang, X., Xu, P., Ding, S., Radosz, M., Shen, Y., Synthesis of 1-(4-vinylbenzyl)thymine and its polymerization by RAFT and ATRP techniques. 227th ACS National Meeting, Anaheim (2004). 1.Xu, P., Radosz, M., and Shen, Y., Core-surface crosslinked micelles fabricated from PCL/PEG brush copolymers. 227th ACS National Meeting, Anaheim (2004).