Yeo lab:Projects

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One of the major obstacles in translating potent drug candidates from bench to bedside is their spatiotemporally adequate delivery. For example, small interfering RNA (siRNA) has been recognized as a promising new class of drugs for viral infections, neurodegenerative diseases, and cancer; however, its therapeutic potential has not been realized because of the instability in circulation and inefficient delivery to the target cells. Target-specific delivery of anti-cancer drugs with minimal side effects on normal tissues has long been a goal for cancer therapy, but their clinical application remains challenging.  
One of the major obstacles in translating potent drug candidates from bench to bedside is their spatiotemporally adequate delivery. For example, small interfering RNA (siRNA) has been recognized as a promising new class of drugs for viral infections, neurodegenerative diseases, and cancer; however, its therapeutic potential has not been realized because of the instability in circulation and inefficient delivery to the target cells. Target-specific delivery of anti-cancer drugs with minimal side effects on normal tissues has long been a goal for cancer therapy, but their clinical application remains challenging.  
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'''Dr. Yeo’s lab''' will focus on developing drug/gene delivery systems which can address these challenges in ‘delivery.Specific research projects include:
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'''Dr. Yeo’s lab''' will focus on developing drug/gene delivery systems which can address these challenges in '''delivery'''. Specific research projects include:
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*Developing leukocyte-mimetic nanoparticles for tumor targeting.
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*Developing nanoparticles for tumor targeting.
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*Pulmonary drug delivery for cystic fibrosis and pulmonary hypertension therapy.
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*Pulmonary drug delivery for local therapy.
*Developing sustained protein delivery systems based on hydrogels and novel microencapsulation techniques for tissue engineering applications.
*Developing sustained protein delivery systems based on hydrogels and novel microencapsulation techniques for tissue engineering applications.
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Revision as of 10:58, 29 January 2007

Laboratory for Therapeutic Particle Engineering

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One of the major obstacles in translating potent drug candidates from bench to bedside is their spatiotemporally adequate delivery. For example, small interfering RNA (siRNA) has been recognized as a promising new class of drugs for viral infections, neurodegenerative diseases, and cancer; however, its therapeutic potential has not been realized because of the instability in circulation and inefficient delivery to the target cells. Target-specific delivery of anti-cancer drugs with minimal side effects on normal tissues has long been a goal for cancer therapy, but their clinical application remains challenging.

Dr. Yeo’s lab will focus on developing drug/gene delivery systems which can address these challenges in delivery. Specific research projects include:

  • Developing nanoparticles for tumor targeting.
  • Pulmonary drug delivery for local therapy.
  • Developing sustained protein delivery systems based on hydrogels and novel microencapsulation techniques for tissue engineering applications.

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