Yoon Sung Nam

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\begin{document} \begin{center} \huge \textbf{Yoon Sung Nam} \vspace{12pt}

\normalsize 77 Massachusetts Avenue, MIT 16-244, Cambridge, MA 02139 \\ Phone: 617-324-3400, E-mail: yoonsung@mit.edu \end{center} \vspace{16pt}

\section{Education and Employment} \begin{itemize} \item Ph.D Program, Biological Engineering (September 2004 - Present) \\ \emph{\textbf{Massachusetts Institute of Technology (MIT)}}, Cambridge, MA. \item Scientific Researcher (March 1999 - August 2004) \\\emph{\textbf{Amore Pacific Corp. R\&D center}}, Yongin, Republic of Korea. \\ \textperiodcentered \quad Nanotechnology Research Team (October 1999 - August 2004) \\ \textperiodcentered \quad Drug Delivery System (DDS) Team (March 1999 - September 1999) \item M.S., Biological Sciences (March 1997 - February 1999) \\ \emph{\textbf{Korea Advanced Institute of Science and Technology (KAIST)}}, Daejon, Republic of Korea, Thesis title: Porous biodegradable polymeric scaffolds prepared by thermally induced phase separation (advised by Prof. Tae Gwan Park). \item B.S., Chemical Engineering (March 1993 - February 1997)\\ \emph{\textbf{Seoul National University (SNU)}}, Seoul, Republic of Korea. \end{itemize}

\section{Research Experience} \begin{itemize} \item \textbf{Graduate Research Assistant} (Angela Belcher Group, MIT) \\March 2007 - present \begin{itemize} \item Developing ion conductive solid electrolytes for electronic devices. \item Generating patterned nanostructures of metal oxide-phage hybrid materials for display technologies. \end{itemize}

\item \textbf{Graduate Research Assistant} (Bevin Engelward Group, MIT) \\ June 2005 - February 2007 \begin{itemize} \item Developed an epifluorescence/two-photon hybrid microscopy system for detection of rare biological events in pancreas (collaboration with Peter So at MIT). \item Studied effect of DNA damaging agents on gene expression in mouse embronic stem cells. \end{itemize}

\item \textbf{Scientific Researcher} (Nanotechnology Research Team and DDS Team, Amore Pacific Corp. R\&D Center) \\October 1999 - August 2004 \begin{itemize} \item Synthesized amphiphilic block- and graft-copolymers for assembling supramolecular nanostructures. \item Developed biodegradable polymeric micelles and vesicles for drug delivery.

   \item Characterized nanostructures using microscopic and scattering techniques.
   \item Studied rheological properties of emulsions stabilized by amphiphilic copolymers and their effects on epidermal sensation.
   \item Set up a formulation and a film manufacturing process for commercialization of a transdermal drug delivery patch product.

\item Developed a prototype implantable hyarulonic acid matrix for controlled release of antibiotics for prevention against osteomyelitis in the event of a car accident. \end{itemize}

\item \textbf{Graduate Research Fellow} (Nano-Biomaterials Group, KAIST) \\ March 1997 - February 1999 \begin{itemize} \item Pioneered surface modification of biodegradable aliphatic polyesters for primary hepatocyte adhesion. \item Developed three-dimensional porous polymer scaffolds for tissue regeneration. \item Pioneered bioconjugation of drugs to biodegradable polymers for controlled drug delivery. \item Studied physicochemical stabilities of therapeutic proteins (\textit{e.g.}, human growth hormone) encapsulated within biodegradable polymer microspheres. \end{itemize}

\item \textbf{Undergraduate Research Assistant} (Biotechnology Group, SNU) \\ March 1996 - December 1996 \begin{itemize} \item Optimized heavy metal adsorption onto algae extract. \end{itemize}

\item \textbf{Summer Intern} (CJ Corporation R\&D Center, Korea) \\ Summer 1995 \begin{itemize} \item Set up a mathematical model for activity of enzymes immobilized within porous polymer beads. \end{itemize} \end{itemize}

\section{Teaching Experience} \begin{itemize} \item Teaching Assitant, Laboratory Fundamentals of Biological Engineering, MIT (Spring 2007) \item Mentor for Thomas S. Pollom (MIT, Biological Engineering), Undergraduate Research Opportunity Program (UROP), MIT (June 2006 - January 2007) \item Teaching Assitant, Laboratory Fundamentals of Biological Engineering, MIT (Spring 2006) \item Teaching Assitant, Biotechnology Laboratory Fundamentals, KAIST (Fall 1997) \end{itemize}

\section{Honors and Awards} \begin{itemize}

 \item DuPont Fellowship (September 2004 - June 2005), DuPont-MIT Alliance Program.

\item Best Poster Finalist, the 5th International Conference on Advanced Polymers via Macromolecular Enginering, Montreal, Quebec, Canada, June 21-26, 2003. \item Japan-Korea Biomaterials Research Young Investigator's Award, the Korean and Japanese Societies for Biomaterials, Makuhari, Chiba, Japan, November 16-17, 1998. \item National Fellowship (March 1997 - February 1999), Ministry of Science and Technology, the Government of the Repulic of Korea. \end{itemize}

\section{Publications}

• Corresponding author

\begin{itemize}

\item DM Wiktor-Brown, HS Kwon, YS Nam, PT So, BP Engelward*, Novel integrated one- and two-photon imaging platform reveals extent of clonal expansion \textit{in situ}, \textit{The EMBO Journal}, To be submitted. \item HS Kwon, YS Nam, DM Wiktor-Brown, BP Engelward, PT So*, Site selective tissue image cytometry captures high resolution images of rare fluorescent cells, \textit{Journal of Biomedical Optics}, To be submitted. \item TA Gaige, HS Kwon, G Dai, VC Cabral, R Wang, YS Nam, BP Engelward, VJ Wedeen, PT So, RJ Gilbert*, Mesoscale myoarchitecture of the mouse tongue derived with diffusion spectrum MRI and multi-photon microscopy, \textit{Biophysical Journal}, To be submitted. \item JS Lee, YS Nam*, BY Kang, SH Han, IS Chang, Vitamin A microencapsulation within poly(methyl methacrylate)-\textit{g}-polyethylenimine microspheres: localized proton buffering effect on vitamin A stability, \textit{Journal of Applied Polymer Science} (2004) 92, 517-522. \item YS Nam*, HS Kang, JY Park, TG Park, SH Han, IS Chang, New micelle-like polymer aggregates composed of PEI-PLGA diblock copolymers: micellar characteristics and cellular uptake, \textit{Biomaterials} (2003) 24, 2053-5059. \item YS Nam*, KJ Kim, HS Kang, TG Park, SH Han, and IS Chang, Chemical immobilization of retinoic acid within poly($\epsilon$-caprolactone) nanoparticles based on drug-polymer bioconjugates, \textit{Journal of Applied Polymer Science} (2003) 89, 1631-1637. \item YC Sim, YS Nam*, YH Shin, ES Shin, SJ Kim, IS Chang, JS Rhee*, Proteolytic enzyme conjugated to SC-glucan as an enzymatic transdermal drug penetration enhancer, \textit{Die Pharmazie} (2003) 58, 252-256. \item YS Nam*, JW Kim, SH Han, IS Chang, Poly(acrylate-co-vinylacetate) adhesive patch for sustained dermal delivery of vitamin A, \textit{Journal of Industrial and Engineering Chemistry} (2003) 9, 2, 153-158. \item YS Nam*, JY Park, SH Han, IS Chang, Intracellular drug delivery using poly(D,L-lactide-co-glycolide) nanoparticles derivatized with a peptide from a transcriptional activator protein of HIV-1, \textit{Biotechnology Letters} (2002) 24, 2093-2098. \item SS Kwon, YS Nam*, JS Lee, BS Ku, SH Han, JY Lee, IS Chang, Preparation and characterization of coenzyme Q10-loaded PMMA nanoparticles by a new emulsification process based on microfluidization, \textit{Colloids and Surfaces A: Physicochemical and Engineering Aspect} (2002) 210, 95-104. \item HS Kang*, SS Kwon, YS Nam, SH Han, IS Chang, Zeta potential determination of polymeric nanoparticles by conductivity variation method, \textit{Journal of Colloids and Interfacial Sciences} (2002) 255, 352-355. \item JJ Yoon, YS Nam, TG Park*, Surface immobilization of galactose onto aliphatic biodegradable polymers for hepatocyte culture, \textit{Biotechnology and Bioengineering} (2002) 78, 1, 1-10. \item KY Cho, SH Choi, CH Kim, YS Nam, TG Park, JK Park*, Protein release microparticles based on the blend of poly(D,L-lactic-co-glycolic acid) and oligo-ethylene glycol grafted poly(L-lactide), \textit{Journal of Controlled Release} (2001) 76, 275-284. \item YS Nam, SH Song, JY Choi, TG Park*, Lysozyme microencapsulation within biodegradable PLGA microspheres: urea effect on protein release and stability. \textit{Biotechnology and Bioengineering} (2000) 5, 70 (3), 270-277. \item YS Nam, JJ Yoon, TG Park*, A novel fabrication method of macroporous biodegradable polymer scaffolds using gas foaming salt as porogen additive, \textit{Journal of Biomedical Materials Research (Applied Biomaterials)} (2000) 53, 1-7. \item YS Nam, TG Park*, Porous biodegradable polymeric scaffolds prepared by thermally induced phase separation, \textit{Journal of Biomedical Materials Research} (1999) 47, 1, 8-17. \item YS Nam, TG Park*, Biodegradable polymeric microcellular foams by modified thermally induced phase separation method, \textit{Biomaterials} (1999) 20, 1783-1790. \item YS Nam, JJ Yoon, JG Lee, TG Park*, Adhesion behaviors of hepatocyte cultured onto biodegradable polymer surface modified by alkali hydrolysis process, \textit{Journal of Biomaterials Science, Polymer Edition} (1999) 10, 11, 1145-1158. \item YS Nam, TG Park*, Protein loaded biodegradable microspheres based on PLGA-protein bioconjugates, \textit{Journal of Microencapsulation} (1999) 16, 5, 625-637. \item JE Oh, YS Nam, KH Lee, TG Park*, Conjugation of drug to poly(D,L- lactic-co-glycolic acid) for zero order controlled release from biodegradable microspheres, \textit{Journal of Controlled Release} (1999) 57, 269-280. \item YS Nam, KH Lee, TG Park*, Conjugation approach of drug to biodegradable poly(D,L-lactic-co-glycolic acid) for controlled release from microspheres, \textit{Polymer Preprints} (1998) 39, 2, 216-217. \item TG Park*, HY Lee, YS Nam, A new preparation method for protein loaded poly(D,L-lactic-co-glycolic acid) microspheres and protein release mechanism study, \textit{Journal of Controlled Release} (1998) 55, 181-191. \end{itemize}

\section{Selected Patents}

\begin{itemize} \item JJ Yoon, TG Park, YS Nam, Preparing porous biodegradable polymeric scaffolds for tissue engineering using effervescent salts, USP 6,586,246 (July 1, 2003). \item JE Oh, KH Lee, TG Park, YS Nam, Controlled drug delivery system using the conjugates of drug to biodegradable polyester, USP 6,589,548 (July 8, 2003). \item YS Nam, HS Kang, SH Han, IS Chang, Amphiphilic biodegradable block copolymers and self-assembled polymer aggregates formed from the same in aqueous milieu, KR2001-036048 (June 23, 2001), EPO 02013696.6- (June 20, 2002), JP 2002-178330 (June 19, 2002), USP 6,569,528 (May 27, 2003). \item JY Park, YS Nam, SH Han, IS Chang, Conjugate of biodegradable aliphatic polyester with Tat49-57 peptide or peptide chain containing Tat49-57 peptide, and nanoparticle manufactured using the same, KR 2002-7328 (May 17, 2002), JP 2002-191104 (June 28, 2002), USP 10-185,593 (June 28, 2002). \item SS Kwon, BH Yoo, YS Nam, BH Kim, BS Ku, SH Han, IS Chang, JS Lee, Percutaneous controlled releasing material using nano-sized polymer particles and external application agent containing the same, KR 2001-19869 (April 13, 2001), JP 2001-174260 (August 6, 2001). \end{itemize}

\section{Presentations} \begin{itemize} \item YS Nam, Preparation of oil-filled nanocapsules by stabilizing the interfaces using amphiphilic block copolymers, Gordon Research Conference on Polymer Colloids, Tilton, New Hampshire, June 29 - July 4, 2003. \item YS Nam, YM Goh, SH Han, IS Chang, Oil-filled polymeric nanocapsules made from amphiphilic block copolymer, the 5th international conference on Advanced Polymers via Macromolecular Enginering, Montreal, Quebec, Canada, 21-26 June 2003. \item YS Nam, JY Park, HS Kang, TG Park, SH Han, IS Chang, Structural characterization of cationic PLGA-PEI self-aggregates and their application for intracellular delivery, the 29th Proceed. International Symposium Controlled Release Bioactive Materials, Controlled Release Society, Seoul, Korea, 22-25 July 2002. \item SS Kwon, YS Nam, SH Han, JW Shim, ES Shin, IS Chang, Coenzyme Q10-loaded PMMA nanoparticles for sustained dermal delivery, the 28th Proceed. International Symposium Controlled Release Bioactive Materials, Controlled Release Society, San Diego, USA, 23-27 June 2001. \item YS Nam, SH Han, JW Kim, SS An, IS Chang, C Chabassol, L Arnaud-Boissel, A new approach for sustained dermal delivery of vitamin A: adhesive patch system, the 28th Proceed. International Symposium Controlled Release Bioactive Materials, Controlled Release Society, San Diego, USA, 23-27 June 2001. \item YS Nam, TG Park, Fabrication of porous poly(D,L-lactic-co-glycolic acid) scaffolds based on thermally-induced phase separation process, The 30th annual meeting of Japanese Society for Biomaterials, Makuhari, Chiba, Japan, 16-17 November 1998. \end{itemize}

\section{Technical Skills} \begin{itemize} \item \textbf{Materials Synthesis}: Ring opening polymerization (aliphatic polyesters), Radical polymerization, Emulsion polymerization, and Bioconjugation (ester, amide, carbanate, etc.). \item \textbf{Fabrication}: PDMS Pattern Stamping, Layer-by-Layer Assembly, Microfluidization, Macroporous polymer scaffolds for tissue engineering, Polymer microspheres for protein delivery, Polymer nanoparticles for drug delivery, Liposomes, Nanoemulsions, Adhesive patch, Cosmetic and pharmaceutical formulations. \item \textbf{Materials Characterization} : Profilometry, Ellispometry, X-ray Photoelectron Spectroscopy, X-ray Diffractometry, Scanning Electron Microscopy, Transmission Electron Microscopy, Confocal Microscopy, Nuclear Magnetic Resonance, Dynamic Light Scattering, Zeta Potential Analysis, Rheometry, Differential Scanning Calorimetry, Gel Permeation Chromatography, Circular Dichroism, and Fluorescence Spectroscopy. \item \textbf{Biological Skills}: DNA manipulation (DNA purification, restriction digestion, gel electrophoresis, and ligation), Polymerase Chain Reaction (including design of primers), Bacterial cell culture, \textit{E.coli} tranformation, Tissue culture (Mouse embryonic stem cells, primary fibroblasts, and P-12 neuron cell line), DNA transfection, Mouse dissection (pancreas and tongue), Protein purification, Protein assays, SDS-PAGE, High Performance Liquid Chromatography, Franz Diffusion Cells, Southern blot, Taqman gene expression assay, and Flow cytometry. \item \textbf{Programming} : Matlab and C language. \end{itemize}

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