Ziyin Li Lab:Notebook/Cell Cycle Regulation in Trypanosomes/2011/06/09: Difference between revisions
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|style="background-color: #EEE"|[[Image:owwnotebook_icon.png|128px]]<span style="font-size:22px;"> | |style="background-color: #EEE"|[[Image:owwnotebook_icon.png|128px]]<span style="font-size:22px;"> Cell Cycle Regulation in Trypanosomes</span> | ||
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Revision as of 07:59, 9 June 2011
Cell Cycle Regulation in Trypanosomes | <html><img src="/images/9/94/Report.png" border="0" /></html> Main project page |
Research
We are also interested in the role of ubiquitin-dependent and -independent proteolysis in various cell biological processes. ATP-dependent protease complexes are present in all three kingdoms of life where they ride the cell of mis-folded or damaged proteins and control the level of certain regulatory proteins. These proteases include the 26S proteasome in eukaryotes, Archaea, and Actinomycetales and the HslVU protease in eubacteria. Currently we are investigating the function and regulation of various ubiquitin-dependent pathways and the ubiquitin-independent HslVU-mediated proteolysis pathway in T. brucei. The current focus is on three proteolytic pathways: the Cullin-RING ubiquitin ligase (CRL) and the anaphase-promoting complex/cyclosome (APC/C) on cell cycle control and HslVU protease on mitochondrial DNA replication licensing.
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