Zrusso Biol 368 week 4: Difference between revisions

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(New page: *# '''What is your question?''' *# '''Make a prediction (hypothesis) about the answer to your question before you begin your analysis.''' *# '''Which subjects, visits, and clones will you ...)
 
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*# '''What is your question?'''
==AIDS At Risk Prediction Project (AARPP)==
*# '''Make a prediction (hypothesis) about the answer to your question before you begin your analysis.'''
 
*# '''Which subjects, visits, and clones will you use to answer your question?'''
*Which six subjects of the fifteen developed AIDS and what were their correlations? i.e. CD4 counts, ds/dn ratios, etc.
*#* You should choose a combination of subjects, visits, and clones that will add up to approximately 50 sequences. You will need about that many sequences to answer a reasonably complex question.  However, you cannot use more because the multiple sequence alignment tool cannot handle more than that many sequences.
*We believe that the median ds/dn ratio will predict which six subjects got AIDS. Therefore, subjects 1,10,4,11,9, and 14 were the ones who developed AIDS
*#* '''Justify why you chose the subjects, visits, and clones you did.'''
**It is simply the CD4 count that determines who has AIDS, so all the rapid progressors have AIDS and no one else does. We now would like to determine who among the remaining subjects is at risk by comparing their ds/dn values and CD4 counts to the AIDS subjects.
**We would also like to determine whether there is any similar clones across the AIDS subjects that indicates an onset of AIDS in the at risk subjects.
*We would like to look at the last visits from subjects across AIDS positive, at risk of AIDS, and not at risk AIDS. This way we have a broad range of data points to compare to subjects with AIDS.
 


{{zrusso Biol 368}}
{{zrusso Biol 368}}

Revision as of 15:49, 21 September 2011

AIDS At Risk Prediction Project (AARPP)

  • Which six subjects of the fifteen developed AIDS and what were their correlations? i.e. CD4 counts, ds/dn ratios, etc.
  • We believe that the median ds/dn ratio will predict which six subjects got AIDS. Therefore, subjects 1,10,4,11,9, and 14 were the ones who developed AIDS
    • It is simply the CD4 count that determines who has AIDS, so all the rapid progressors have AIDS and no one else does. We now would like to determine who among the remaining subjects is at risk by comparing their ds/dn values and CD4 counts to the AIDS subjects.
    • We would also like to determine whether there is any similar clones across the AIDS subjects that indicates an onset of AIDS in the at risk subjects.
  • We would like to look at the last visits from subjects across AIDS positive, at risk of AIDS, and not at risk AIDS. This way we have a broad range of data points to compare to subjects with AIDS.


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Assignment Pages

BIOL368/F11:Week 7

BIOL368/F11:Week 8

BIOL368/F11:Week 9

BIOL368/F11:Week 10

BIOL368/F11:Week 11

BIOL368/F11:Week 12

BIOL368/F11:Week 14