20.109(F11): Mariana Duran and Divya Chhabra
Using Targeted Nanoparticles Containing Anti Beta-Amyloid Compounds in Alzheimer's Patients
Alzheimer's disease is a form of dementia that affects memory, thinking, and behavior and gets progressively worse over time. Currently, there is no known cure or effective treatment for Alzheimer's. High amounts of beta-amyloid(Aβ) peptide are found in Alzheimer's patients. Previous studies indicate that high levels of Aβ lead to plaque formation within the brain which is a factor in the onset of Alzheimer's disease. Anti-Aβ drugs found in the past have not lead to significant improvements in cognitive function. However, it is postulated that the methods of delivery and administration may be the root cause of failure as opposed to the drug itself.
We hope to modify the method of delivery of these drugs by loading them in Aβ-targeted nanoparticles.