20.949/F10:Schedule

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Date Topic Assignment
September 9 Overview of Synthetic Biology
September 14 Biophysical Models of Basic Biological Processes I
September 16 Biophysical Models of Basic Biological Processes II
September 21 Noise propagation and regulatory feedback
September 23 Computational modeling of genetic circuits (ODE, stochastic, Lambda)
September 28 Dynamics of Biological Circuits -- Feed-forward motifs
September 30 Dynamics of Biological Circuits -- Toggle switches and bistability
September 30 Dynamics of Biological Circuits -- Oscillators
October 5 Dynamics of Biological Circuits -- Bifurcation analysis / phase space
October 7 Cell-cell communication I
October 12 Cell-cell communication II
October 14 RNA regulation (bacterial / microbial)
October 19 RNA regulation (Eukarytoic)
October 21 Protein tagging: secretion / localization / degradation
October 26 Protein engineering (modular design of proteins) to explore functional
October 28 Protein-protein interaction networks
November 2 Metabolic engineering
November 4 Interfacing to other cell functions
November 9 Principles of design -- from parts to modules to systems I
November 11 Principles of design -- from parts to modules to systems II
November 16 Principles of design -- from parts to modules to systems III
November 18 Principles of design -- from parts to modules to systems IV
November 23 Directed evolution (parts & circuits)
November 30 History of DNA manipulation
December 2 Advanced DNA design & cloning
December 7 Synthetic biology applications
December 9 Synthetic Life / Perspectives & challenges
December X-Y Term project presentations
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