6.021/Notes/2006-11-08

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Cable model

  • The cable model is linear approximation of Hodgkin-Huxley model for small signals
  • If the change in membrane voltage is small, than the change in m, n, and h are all small so we can ignore
  • Thus all conductances are constant
  • J_m = C_m\frac{dV_m}{dt}+G_m(V_m-V_m^o)
  • Cable Equation: v_m+\tau_m\frac{\partial v_m}{\partial t}-\lambda_c^2\frac{\partial^2v_m}{\partial z^2}=r_o\lambda_c^2K_e
    • \tau_m=\frac{c_m}{g_m} (independent of cell size)
    • \lambda_c = \frac{1}{\sqrt{g_m(r_o+r_i)}}
    • v_m = V_m - V_m^o
  • Lord Kelvin (1855)
    • problem of putting cable under Atlantic for telegraphy
    • made with copper and tar surrounded by sea water
    • Same problem as axon + membrane
  • Assume infintesmal electrode to a remote electrode
  • Given a pulse of current stimulus, look at steady state response
    • v_m-\lambda_c^2\frac{\partial^2v_m}{\partial z^2}=r_o\lambda_c^2K_e
    • solution: v_m(z) = \frac{r_o\lambda_c}{2}I_e e^{-|z|/\lambda_c}
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