BME100 f2013:W900 Group18 L2

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Contents

OUR TEAM

Name: Daniel McDermand
Name: Daniel McDermand
Name: Nick Vale
Name: Nick Vale
Name: Dylan DeBruin
Name: Dylan DeBruin
Name: Kirstin Peters
Name: Kirstin Peters
Name: Matt Hanson
Name: Matt Hanson

LAB 2 WRITE-UP

Descriptive Statistics

Experiment 1: Human Study
0mg:
Mean- 3.834
Standard Deviation- 1.523010177
Endpoint- 10
Standard Error- 0.481618106

5mg:
Mean- 8.932
Standard Deviation- 1.59393155
Endpoint- 10
Standard Error- 0.50404541

10mg:
Mean- 6.622
Standard Deviation- 30.1106939
Endpoint- 10
Standard Error- 9.52183745

15mg:
Mean- 657.941
Standard Deviation- 212.942976
Endpoint- 10
Standard Error- 67.3384817



Experiment 2: Rat Study
0mg:
Mean- 10.516
Standard Deviation- 2.225551617
Endpoint- 5
Standard Error- 0.995296941

10mg:
Mean- 11.112
Standard Deviation- 7.40288592
Endpoint- 5
Standard Error- 3.31067123

This section was worked on by Dylan, Daniel, and Nick.

Results

Experiment 1 Image:Humans3.png

  • all lines indicate significant difference

Experiment 2 Image:Rats.png





Analysis

In the first experiment with humans, an ANOVA test was conducted resulting in a p-value of 1.40E-16. After Bonferonni correction, the new alpha level was set at 8.33E-3 (rather than .05). Since the p-value was less than 8.33E-3, we can conclude that there is a statistically significant difference between levels of dosage of LPS in humans. In the second experiment with rats, a T-test was conducted resulting in a p-value of .8674035. Since the p-value was greater than .05, we can conlude that there is no statistically significant difference between levels of LPS dosage in rats.

Worked on by Daniel and Dylan






Summary/Discussion

It was concluded that there is a statiscally significant difference in the Inflammotin levels in humans when the dosage of LPS is increased. In humans, the doses of LPS between 0mg and 10mg produced less variance of Inflammotin levels than when a dose of 15 mg was given to the subjects. However, when the experiment was repeated on rats, the increase in the dosage of LPS did not yield as large of a difference in Inflammotin levels. Providing the human subjects with 15mg of LPS caused them to produce over 100 times the amount of Inflammotin that occurred when giving them 0mg to 10mg. After testing the rats, the results yielded a p-value of .8674035, meaning the results were insignifcant because the p-value was greater than .05 (averages were too close together).

Worked on by Kirstin Peters & Matt Hanson & Nick Vale






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