# BME100 f2016:Group11 W1030AM L3

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# OUR TEAM

 Andrea Grio Sonya Baran Saul Vidrios Joshua Hsu Jake Perrine

# LAB 3 WRITE-UP

## Inferential Stats

Based on the data obtained through the two tailed tests, it can be confirmed that the spree did not relay accurate information when it tested the temperature of the subjects. Although the average values were similar, the variance between the data were off by nearly 96%. This can further be proven when comparing the p-value obtained from the temperature data chart, which was p=0.01, to the known p-value of p=0.05. Because the measured p-value was 16% lower than the known value, the spree's data is known to be unreliable. The data obtained from measuring the heart rate, however, was extremely accurate. The compared p-value is p=0.72, and since it is more than 5%, it shows that the spree is capable of relaying accurate information in terms of heart rate. When analyzing the graphs, the similarity between the spree and the gold-standard become more apparent, considering the averages and the standard deviations are nearly identical.

## Design Flaws and Recommendations

We are evaluating the Spree headband’ claims of accurate heart rate and body temperature measurements. We are using a pulse oximeter and an internal thermometer as the ‘gold standard’ in this comparisons. A gold standard allows us to compare how by what magnitude does the Spree headband’s measurements differ.

For the heartrate, the averages were about the same and the scatterplots trend line was similar as well, albeit there was some discrepancy within the plots. The heartrate is fairly accurate on the Spree but not up to the Gold Standard.

On the other hand, the temperature measurement seems to be off by a larger margin with constant spree temperature, not matching up with the actual temperature. This means that even though the thermometer is reading different temperature, the spree is only reading one, despite the changes. This indicates a shortcoming in terms of the Spree’s temperature measuring capabilities. Sources of error in the Spree headband could be due to improper placement of the headband, so human error or the location or capabilities of the sensor being diminished due to the increased physical and its production of movement and sweat.

## Experimental Design of Own Device

Our device will be tested on how well it filters waste from the blood. The pH of blood is a good way to measure how much waste is in the blood. Normally the pH of blood is around 7.4 when the kidneys are functioning at their full potential. Dialysis takes over the function of the kidney and must keep the blood at that pH. The experiment would contain a group of 50 participants, with FDA approval, suffering from stage 4 kidney disease or kidney failure. The experiment will be a paired t-test, where the participant's blood is taken before and after using the device. Participants will need to get vascular access surgery to connect to the device 3 weeks prior to the experiment. Before the experiment, the participant will be taken off any kind of dialysis for 24 hours leading up to the test. This will make sure that there is as much waste that has accumulated in the participant as there would be in between dialysis treatment. The participant's blood will then be taken and the pH measured. Then the participant will put on the device, wear it for 24 hours and then have their blood taken and measured. Twenty-four hours gives The device adequate time to filter the blood and make sure it is functioning at all times. The two measures of pH of the blood will then be compared to the average standard pH of blood (7.4) to see if the device is properly functioning. We can analyze the results to see not only if the device filtered the blood but how well the blood was filtered.