BME100 s2014:W Group5 L1

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Inflammotin: An Inflammatory Protein Found in the Elderly

In the following experiment, elderly subjects will be administered varying doses of
lipopolysaccharide (an inflammation-inducing agent) in order to increase the
inflammatory protein Inflammotin (measured in μg/mL). Lipopolysaccharide will be
treated as the independent variable and Inflammotin the dependent variable. Fifty
subjects will be randomly distributed into five equal groups given
lipopolysaccharide 0.0 mg (placebo), 2.5 mg, 5.0 mg, 7.5 mg or 10.0 mg
respectively.

The tested subjects will be within the range of sixty-five and
eighty-five years of age. They will be selected from various locations in the
Phoenix-metropolitan area. The subjects are assumed to be healthy enough to
participate for the entire course of the trial.

Potential sources of error
include: subject-compliance, group distribution and interference with other
medications. In order to control for these factors, the drug will be
administered under the supervision of a researcher, the experiment will be
conducted several times and subjects will submit a medication list including drugs
and dosages.

The data will be analyzed using analysis of variance (ANOVA)
with a significance level of 0.05.
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