BME100 s2015:Group2 9amL5
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LAB 5 WRITE-UP
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Representative Images of Negative and Positive Samples
SNP Information & Primer Design
Background: About the Disease SNP
A nucleotide is a bundle of amino acids that serve as building blocks for DNA. A polymorphism is a variation of phenotypes within a select group population. The single nucleotide polymorphism (SNP) rs268 is found in Homo sapiens (Human). The chromosome this variation is located on is 8. The listed clinical significance of this SNP is pathogenic. The genes this SNP is associated with are NHGRI, GWAS, and PheGenl. Coronary heart disease is linked to this SNP. LPL stands for lipoprotein lipase. The functions of LPL include: apolipoprotein binding, heparin binding, and lipoprotein lipase activity. An allele is a variation of a gene usually brought to pass by a mutation. The sequence of the disease-associated allele is AGT. The position of the SNP is 19956018.
The results of the primer test of the DNA sequences of diseased and non-diseased primers were successful in that the expected outcome was achieved. A match was found with the non-diseased primer because the human genome produces this healthy primer on its own while no match was found when the diseased primer was tested because the human genome produce the mutation that was present in the diseased primer.