BioControl:Week3-12

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Best of 2006-2007

Best of 2007-2008

Past Reading

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Next meeting

  • 11/19 at 10am in the Steele library.

Topics

  • Activity motifs
  • principles of timing
  • transcriptional control
  • yeast
  • metabolic networks

Reading

  1. Chechik G, Oh E, Rando O, Weissman J, Regev A, and Koller D. . pmid:18953355. PubMed HubMed [stricker]

Comments

Promising, but ultimately disappointing. The curve fitting to the mRNA data was not convincing (the shape of the data did not match the fit). Measurements (mRNA and ChIP-chip in particular) should probably have large error bars, bringing fine distinctions in timing or affinity into question. Time resolution was also questionable - the first measurement was taken at 15 minutes, but differences in activation time of 3 minutes vs. 4 minutes were treated as significant. No data was presented to support the claim on correlation between binding affinity motifs and transcriptional activation motifs, and the conclusions were presented in a confusing fashion (why claim that 20/48 data sets showed correlation, rather than breaking things out by individual motifs?).

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