Abstract Recently we designed a complex drug delivery
system named DNA spaceship for tumor therapy.
The main body of our DNA spaceship is DNA
origami and drugs are loaded inside. Magnetic
nanoparticles(Fe3O4) are modified on our DNA
origami to control the transportation of the DNA
origami more precisely by applying magnetic field.
The opening of DNA origami (release of drugs
inside) is controlled by light signal. We could use
light signals of varying intensity to open different
DNA origamis and release different drugs. This
kind of light control is achieved by Au
nanoparticles modified on DNA origami. In
conclusion, drugs can be precisely delivered to the
tumor cells without damaging normal cells and
drug release is controlled by light signal.