Biomod/2014/future.html

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We have successfully built the device which is made of gold nanoparticles, three arm lockers and DNA origami. And we have great faith in an even broader perspective of its future development, owing to combination of the various possible function of DNA origami and the accurate remote controlling of light.


Furthermore, we are considering to develop our device by adding magnetic nanoparticles. As we have known, the magnetic nanoparticles covered by the gold shell has been reported and brought on stream. If we contain the element of magnetic nanoparticles, we may have the chance to establish a double physical control mechanism that both the light and the magnetic field targeting the destination in vivo. So, the device can not only do fixed point opening, but also achieve orientation movement.


In addition, DNA origami is a well- known carrier for drugs delivery, especially the anti- tumor drug. And our device has twofold benefits for treating:

(1)The photothermal property can be used in the thermal therapy process.

(2)The anti- tumor drug’s controllable releasing.

Figure 1. Our device as drugs delivery in vivo.
Figure 1. Our device as drugs delivery in vivo.

In this case, we are hoping to build a new thought for therapy of disease.


Besides, we plan to text different gold nanoparticles with variety diameter correlated with different density and wavelength of light. Also, we are trying different shapes of DNA origami, such as hexagonal prisms, in order to realize more application.

Figure 2. Hexagonal prisms origami as drugs delivery in vivo.
Figure 2. Hexagonal prisms origami as drugs delivery in vivo.

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