Our main interest is to better understand the cellular and molecular basis for generation and maintenance of regulatory T cells (Tregs) in the suppression of autoimmunities and/or allergies in mouse models. We have been using intravital microscopy as the starting point for the in vivo imaging of Tregs. We are evaluating what and where the important cell-cell contacts for Tregs generation/function happen. For that, we are using multi-photon microscopy, developing new intravital surgical tecniques and tools, and using animal models that develop autoimmune and allergic diseases. We hope that a better comprehension of generation and function of Tregs will be crucial for the development of new therapies against human autoimmune and allergic diseases. Our lab is located at the Unit of Cell Imaging, IGC, Portugal.
- Kim JV, Jiang N, Tadokoro CE, Liu L, Ransohoff RM, Lafaille JJ, and Dustin ML. . pmid:19800886.
- Maraver A, Tadokoro CE, Badura ML, Shen J, Serrano M, and Lafaille JJ. . pmid:17626841.
- Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, Cua DJ, and Littman DR. . pmid:16990136.