Simon W.-L. Chan
University of California, Davis
Department of Plant Biology
1 Shields Ave.
Davis, CA 95616
(530) 754 9652
Education and Research Experience
July 2006- University of California, Davis, Davis, CA Assistant Professor
2002-2006 University of California, Los Angeles, Los Angeles, CA Postdoctoral fellowship Advisor: Dr. Steven E. Jacobsen
1996-2002 University of California, San Francisco, San Francisco, CA Ph.D. in Cell Biology. Advisor: Dr. Elizabeth H. Blackburn
1992-1995 University of Auckland, Auckland, New Zealand Bachelor of Science (with Honours) in Biochemistry. Advisor: Dr. Nigel P. Birch
2010 Basil O’Connor Starter Scholar Award, March of Dimes
2006 American Society of Plant Biologists Early Career Award
2004 UCLA Boyer-Parvin Postdoctoral Award
2003-2006 Life Sciences Research Foundation Postdoctoral Fellowship (sponsored by the U.S. Department of Energy, Energy BioSciences division)
1997-2002 Howard Hughes Medical Institute Predoctoral Fellowship
2008 National Academies Education Fellow in the Life Sciences (attended The National Academies Summer Institute on Undergraduate Education in Biology).
2003 QB3 Microarray Course at UC Santa Cruz (taught by Dr. Joseph Derisi and colleagues).
Ravi, M. and Chan, S.W.L. Haploid plants produced by centromere-mediated genome elimination. Nature in press (2010)
Henderson, I.R., Chan, S.R., Cao, X., Johnson L. and Jacobsen S.E. Accurate sodium bisulfite sequencing in plants. Epigenetics in press (2010)
Chan, S.W.L. Inputs and outputs for chromatin-targeted RNAi. Trends in Plant Sciences 7, 383-389 (2008)
Chan, S.W.L., Zhang, X., Bernatavichute, Y.V. and Jacobsen, S.E. Two-step recruitment of RNA-directed DNA methylation to tandem repeats. PLoS Biology 4, e363 (2006)
Peng, P., Chan, S.W.L., Shah, G., and Jacobsen, S.E. Elevated outcrossing in hothead mutants. Nature 443, E8 (2006)
Zhang, X.*, Yazaki, J.*, Sundaresan, A*., Cokus, S*, Chan, S.W.L., Chen, H., Henderson, I.R., Shinn, P., Pellegrini, M., Jacobsen, S.E. and Ecker, J.R. Genome-wide high-resolution mapping and functional analysis of DNA methylation in Arabidopsis. Cell 126, 1189-1201 (2006)
Li, C.F, Pontes, O., El-Shami, M., Henderson, I.R., Bernatavichute, Y.V., Chan, S.W.L., Lagrange, T., Pikaard, C.S. and Jacobsen, S.E. An ARGONAUTE4-containing nuclear processing center co-localized with Cajal bodies in Arabidopsis thaliana. Cell 126, 93-106 (2006)
Chan, S.W.L., Henderson, I.R., Zhang, X., Chien, J., Shah, G. and Jacobsen, S.E. RNAi, DRD1 and histone methylation actively target developmentally important non-CG DNA methylation in Arabidopsis. PLoS Genetics 2, e83 (2006)
Chan, S.W.L.*, Henderson, I.R.* and Jacobsen, S.E. Gardening the genome: DNA methylation in Arabidopsis thaliana. Nature Reviews Genetics 6 351-360 (2005) [review article]
Mockler, T.C., Chan, S., Sundaresan A., Chen, H., Jacobsen S.E. and Ecker, J.R. Applications of DNA tiling arrays for whole-genome analysis. Genomics 85 1-15 (2005) [review article]
Morris, K.V., Chan, S.W.L., Jacobsen, S.E. and Looney, D.J. siRNA-induced transcriptional gene silencing in human cells. Science 305, 1289-1292 (2004)
Chan, S.W.L., Zilberman D., Xie, Z., Johansen, L.K., Carrington, J.C. and Jacobsen, S.E. RNA silencing genes control de novo DNA methylation. Science 303, 1336 (2004)
Chan, S.R.W.L. and Blackburn, E.H. Telomeres and telomerase. Phil. Trans. R. Soc. Lond. B 359, 109-121 (2004)
Chan, S.W.L. and Blackburn, E.H. Telomerase and ATM/Tel1p protect telomeres from non-homologous end-joining. Molecular Cell 11, 1379-1387 (2003)
Chan, S.W.L. and Blackburn, E.H. New ways not to make ends meet. Oncogene 21, 553-563 (2002) [review article].
Chan, S.W.L., Chang, J., Prescott, J. and Blackburn, E.H. Altering telomere structure allows telomerase to act in yeast lacking ATM kinases. Current Biology 11, 1240-1250 (2001).
Blackburn, E.H., Chan, S., Chang, J., Fulton, T.B., Krauskopf, A., McEachern, M., Prescott, J., Roy, J., Smith, C. and Wang, H. Molecular manifestations and molecular determinants of telomere capping. Cold Spring Harbor Symposia on Quantitative Biology, 65, 253-263 (2000)
* denotes equal contribution
Invited seminar, Temasek Life Sciences Laboratory, Singapore June 2009
Invited talk, International Plant Epigenome conference, Sydney, Australia September 2008
Invited seminar, University of Wisconsin at Madison July 2008
American Society for Cell Biology