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The Methodist Hospital Research Institute, Houston, Texas.
You can also visit my homepage at: Fanglab

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1. Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia. Liu C, Gates KP, Fang L, Amar MJ, Schneider DA, Geng H, Huang W, Kim J, Pattison J, Zhang J, Witztum JL, Remaley AT, Dong PD, Miller YI. Dis Model Mech. 2015 Aug 1;8(8):989-98. doi: 10.1242/dmm.019836. Epub 2015 Jun 4. PMID:26044956

2. Polo-like kinase 2 regulates angiogenic sprouting and blood vessel development. Yang H, Fang L, Zhan R, Hegarty JM, Ren J, Hsiai TK, Gleeson JG, Miller YI, Trejo J, Chi NC. Dev Biol. 2015 Aug 15;404(2):49-60. doi: 10.1016/j.ydbio.2015.05.011. Epub 2015 May 22. PMID:26004360

3. Oxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2 (SREBP2) transactivation of microRNA-92a. Chen Z, Wen L, Martin M, Hsu CY, Fang L, Lin FM, Lin TY, Geary MJ, Geary GG, Zhao Y, Johnson DA, Chen JW, Lin SJ, Chien S, Huang HD, Miller YI, Huang PH, Shyy JY. Circulation. 2015 Mar 3;131(9):805-14. doi: 10.1161/CIRCULATIONAHA.114.013675. Epub 2014 Dec 30. PMID:25550450


1. Zebrafish models of dyslipidemia: relevance to atherosclerosis and angiogenesis. Fang L, Liu C, Miller YI. Transl Res. 2014 Feb;163(2):99-108. doi: 10.1016/j.trsl.2013.09.004. Epub 2013 Oct 2. Review. PMID:24095954


1. Targeted cholesterol efflux. Fang L, Miller YI. Cell Cycle. 2013 Nov 1;12(21):3345-6. doi: 10.4161/cc.26401. Epub 2013 Sep 13. No abstract available. PMID:24036659

2. Control of angiogenesis by AIBP-mediated cholesterol efflux. Fang L, Choi SH, Baek JS, Liu C, Almazan F, Ulrich F, Wiesner P, Taleb A, Deer E, Pattison J, Torres-Vázquez J, Li AC, Miller YI. Nature. 2013 Jun 6;498(7452):118-22. doi: 10.1038/nature12166. Epub 2013 May 29. PMID:23719382


1. Emerging applications for zebrafish as a model organism to study oxidative mechanisms and their roles in inflammation and vascular accumulation of oxidized lipids. Fang L, Miller YI. Free Radic Biol Med. 2012 Oct 1;53(7):1411-20. doi: 10.1016/j.freeradbiomed.2012.08.004. Epub 2012 Aug 11. Review. PMID:22906686

2. Ezetimibe and simvastatin reduce cholesterol levels in zebrafish larvae fed a high-cholesterol diet. Baek JS, Fang L, Li AC, Miller YI. Cholesterol. 2012;2012:564705. doi: 10.1155/2012/564705. Epub 2012 May 30. PMID:22693663


1. In vivo visualization and attenuation of oxidized lipid accumulation in hypercholesterolemic zebrafish. Fang L, Green SR, Baek JS, Lee SH, Ellett F, Deer E, Lieschke GJ, Witztum JL, Tsimikas S, Miller YI. J Clin Invest. 2011 Dec;121(12):4861-9. doi: 10.1172/JCI57755. Epub 2011 Nov 21. PMID:22105168

2. Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity. Miller YI, Choi SH, Wiesner P, Fang L, Harkewicz R, Hartvigsen K, Boullier A, Gonen A, Diehl CJ, Que X, Montano E, Shaw PX, Tsimikas S, Binder CJ, Witztum JL. Circ Res. 2011 Jan 21;108(2):235-48. doi: 10.1161/CIRCRESAHA.110.223875. Review. PMID:21252151


1. Oxidized cholesteryl esters and phospholipids in zebrafish larvae fed a high cholesterol diet: macrophage binding and activation. Fang L, Harkewicz R, Hartvigsen K, Wiesner P, Choi SH, Almazan F, Pattison J, Deer E, Sayaphupha T, Dennis EA, Witztum JL, Tsimikas S, Miller YI. J Biol Chem. 2010 Oct 15;285(42):32343-51. doi: 10.1074/jbc.M110.137257. Epub 2010 Aug 14. PMID:20710028

2. Toll-like receptor-4 and lipoprotein accumulation in macrophages. Miller YI, Choi SH, Fang L, Harkewicz R. Trends Cardiovasc Med. 2009 Oct;19(7):227-32. doi: 10.1016/j.tcm.2010.02.001. Review. PMID:20382346

3. Lipoprotein modification and macrophage uptake: role of pathologic cholesterol transport in atherogenesis. Miller YI, Choi SH, Fang L, Tsimikas S. Subcell Biochem. 2010;51:229-51. doi: 10.1007/978-90-481-8622-8_8. Review. PMID:20213546


1.Proteomic, functional and motif-based analysis of C-terminal Src kinase-interacting proteins. Yang G, Li Q, Ren S, Lu X, Fang L, Zhou W, Zhang F, Xu F, Zhang Z, Zeng R, Lottspeich F, Chen Z. Proteomics. 2009 Nov;9(21):4944-61. doi: 10.1002/pmic.200800762. PMID:19743411

2.Vascular lipid accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafish. Stoletov K, Fang L, Choi SH, Hartvigsen K, Hansen LF, Hall C, Pattison J, Juliano J, Miller ER, Almazan F, Crosier P, Witztum JL, Klemke RL, Miller YI. Circ Res. 2009 Apr 24;104(8):952-60. doi: 10.1161/CIRCRESAHA.108.189803. Epub 2009 Mar 5. PMID:19265037


1.Proteome identification of binding-partners interacting with cell polarity protein Par3 in Jurkat cells. Zhou Y, Fang L, Du D, Zhou W, Feng X, Chen J, Zhang Z, Chen Z. Acta Biochim Biophys Sin (Shanghai). 2008 Aug;40(8):729-39. PMID:18685789


1.Cell polarity protein Par3 complexes with DNA-PK via Ku70 and regulates DNA double-strand break repair. Fang L, Wang Y, Du D, Yang G, Tak Kwok T, Kai Kong S, Chen B, Chen DJ, Chen Z. Cell Res. 2007 Feb;17(2):100-16. Erratum in: Cell Res. 2007 Jun;17(6):572-4. PMID:17287830


1.Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling. Wang Y, Du D, Fang L, Yang G, Zhang C, Zeng R, Ullrich A, Lottspeich F, Chen Z. EMBO J. 2006 Nov 1;25(21):5058-70. Epub 2006 Oct 19. PMID:17053785

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