IGEM:PennState/Labbook/Nimrah Ahmed/2008/05/28

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PPAR & Thalates

  • Reference material on CMS. Lots of it.

Briefly:

  • Peroxisomes are subcellular organelles, found in

most animal cells, that perform diverse metabolic functions, including H2O2-derived respiration, boxidation of fatty acids, and cholesterol metabolism (Lock et al., 1989).


  • Peroxisome proliferator

chemicals (PP) are a large class of structurally dissimilar industrial and pharmaceutical products that were originally identified as inducers of peroxisomes in the livers of exposed mice and rats.

  • A subset of nuclear receptor superfamily members

called peroxisome proliferator-activated receptors (PPAR) play pivotal roles in mediating many, if not all, of the adaptive consequences of PP exposure. PP activate PPAR in most cases by binding directly to the receptor, leading to the altered regulation of genes involved in lipid metabolism and peroxisome proliferation, as well as genes involved in determining cell fate (Corton et al., 2000).


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