JHIBRG:Abstract Jan 11 2007

From OpenWetWare

Jump to: navigation, search


Investigating candidate genes for Alzheimer’s disease with depression

Eunchai Kang

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by cognitive deterioration with declining activities, often exhibits psychiatric symptoms like depression. The previous study shows Chr7 q32.3-35 region is associated with Alzheimer’s disease when depression is used as a covariate. To identify the shared genetic susceptibility between AD and depression, I examined this region to find candidate genes. Among 85 genes in this region, 3 genes (CHRM2, CASP2, GSTK1) were selected based on association to AD, depression or biological relevance found in previous studies. A single-nucleotide polymorphism (SNP) genotyping screen of this 3 genes (35 SNPs) were performed, and the SNPs that can represent linkage disequilibrium block were chosen. For statististical Analysis, family based association test was done by using FBAT software.

Personal tools