Smolke:Kelsic:11-1-06 talk

Summary

• It is useful to have independent control of cellular physical quantities.
• Outline of a system for controlling the mean and variance of protein expression population distributions.

Information

• given by Eric Kelsic to the Smolke Lab on 11-1-06
• PowerPoint slides

References

1. Ozbudak EM, Thattai M, Kurtser I, Grossman AD, and van Oudenaarden A. . pmid:11967532. PubMed HubMed [Ozbodak]
2. Becskei A and Serrano L. . pmid:10850721. PubMed HubMed [Becskei]
3. Swain PS. . pmid:15544806. PubMed HubMed [Swain]
4. Smolke CD, Carrier TA, and Keasling JD. . pmid:11097920. PubMed HubMed [Smolke]
5. Carrier TA and Keasling JD. . pmid:9933514. PubMed HubMed [Carrier]
6. Lamontagne B and Elela SA. . pmid:14581474. PubMed HubMed [Lamontagne]

Additional

• for more on the ideas of independence and reachability, look into control theory. Richard Murray at Caltech is working on a text, which is online: Feedback Systems - An Introduction for Scientists and Engineers. Also, the idea of observability is interesting to think about, in terms of what cellular processes we can study and understand.
  • Chapter 6 - State Feedback - Reachability
  • Chapter 7 - Output Feedback - Observability
• Also, the slides are best viewed with the soundtrack of MC Hammer's U Can't Touch This, a thoughtful piece on man's ability to use tools (symbolically the hammer) to manipulate and understand nature.

Comments

• please leave comments or feedback here: -Kelsic

• "sweetness is my weakness" - MC Hammer / Tsbayer