User:Curt Fischer

Curt Fischer Laboratory for Bioinformatics and Metabolic Engineering Department of Chemical Engineering 77 Massachusetts Ave. 56-422 Cambridge, MA 02139 +1 (617) 253-6591

Research Interests

My work involves the creation of new molecular tools and analyses which enable the metabolic engineering of microorganisms. For my Ph.D. thesis, I'm focusing on the production of two model pathways (for tyrosine and lycopene biosynthesis), and exploring new ways to control and optimize gene expression for increased productivity.

Education

M.Eng.	Bioengineering	Tokyo Institute of Technology
B.S.	Chemical Engineering	Case Western Reserve University

Data for Stephanopoulos Lab Members Only

• Strain Archive This Excel file refers to freezer boxes I have in the -80 C freezer in the southeast corner of the lab.

Publications

1. Nevoigt E, Kohnke J, Fischer CR, Alper H, Stahl U, and Stephanopoulos G. Engineering of promoter replacement cassettes for fine-tuning of gene expression in Saccharomyces cerevisiae. Appl Environ Microbiol. 2006 Aug;72(8):5266-73. DOI:10.1128/AEM.00530-06 |
2. Styczynski MP, Fischer CR, and Stephanopoulos GN. The intelligent design of evolution. Mol Syst Biol. 2006;2:2006.0020. DOI:10.1038/msb4100065 |
3. Jensen K, Alper H, Fischer C, and Stephanopoulos G. Identifying functionally important mutations from phenotypically diverse sequence data. Appl Environ Microbiol. 2006 May;72(5):3696-701. DOI:10.1128/AEM.72.5.3696-3701.2006 |
4. Fischer CR, Alper H, Nevoigt E, Jensen KL, and Stephanopoulos G. Response to Hammer et al.: Tuning genetic control--importance of thorough promoter characterization versus generating promoter diversity. Trends Biotechnol. 2006 Feb;24(2):55-6. DOI:10.1016/j.tibtech.2005.12.001 |
5. Alper H, Fischer C, Nevoigt E, and Stephanopoulos G. Tuning genetic control through promoter engineering. Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12678-83. DOI:10.1073/pnas.0504604102 |
6. Fischer CR, Yoichi M, Unno H, and Tanji Y. The coexistence of Escherichia coli serotype O157:H7 and its specific bacteriophage in continuous culture. FEMS Microbiol Lett. 2004 Dec 15;241(2):171-7. DOI:10.1016/j.femsle.2004.10.017 |
7. Mizoguchi K, Morita M, Fischer CR, Yoichi M, Tanji Y, and Unno H. Coevolution of bacteriophage PP01 and Escherichia coli O157:H7 in continuous culture. Appl Environ Microbiol. 2003 Jan;69(1):170-6. DOI:10.1128/AEM.69.1.170-176.2003 |
8. Morita M, Fischer CR, Mizoguchi K, Yoichi M, Oda M, Tanji Y, and Unno H. Amino acid alterations in Gp38 of host range mutants of PP01 and evidence for their infection of an ompC null mutant of Escherichia coli O157:H7. FEMS Microbiol Lett. 2002 Nov 5;216(2):243-8. DOI:10.1111/j.1574-6968.2002.tb11442.x |