User:Andy Maloney/Kinesin & Microtubule Page/Surface passivation/The Sialoadhesins a family of sialic acid dependent cellular recognition molecules within the immunoglobulin superfamily

Disclaimer

These are my notes. Please read the paper before reading my notes.

Paper

The Sialoadhesins--a family of sialic acid-dependent cellular recognition molecules within the immunoglobulin superfamily.

Notes

• Sialic acids contribulte to cell surface diversity.
  • There are many modifications to the sialic acid that we know of.
  • Common mamalian sialic acids include:
    • Neu5Ac
    • Neu5,8Ac₂
    • Neu5Gc
  • They appear at terminal positions on sugars like:
    • Gal
    • GalNAc
    • GlcNAc
  • They can be at the ends of glycoproteins and glycolipids as well.
• Selectins adhere to sialic acid residues.
  • They recognize amino acid sequences
  • Typically they are transmembrane proteins.
  • Kinectin is an example of a selectin.
• Sialoadhesion could be used to block sialic acid residues on casein.
• The article is about a familiy of proteins that recognize and attach to sialic acids.