User:Daniel M Jordan

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Contact Info

Daniel M Jordan (an artistic interpretation)
Daniel M Jordan (an artistic interpretation)
  • Daniel M Jordan
  • Graduate Student in Biophysics
  • Laboratory of Shamil R. Sunyaev
  • Division of Genetics, Department of Medicine
  • Brigham and Women's Hospital and Harvard Medical School
  • Email me through OpenWetWare

Education

  • 2006, BA Physics & Philosophy, Yale University

Research interests

My main interest is in modeling the relationship between protein structures and evolutionary processes. To briefly summarize: in principle, molecular biology tells us that most functional mutations should be functional because they modify the structure of a protein. Interpreting the functional effect of mutations based on their effects on protein structures has not been terribly fruitful so far -- the most successful methods use primarily phylogenetic information. One major area of my research involves attempting to develop protein structure based heuristics that can improve functional predictions for mutations. I have had some success with developing such heuristics for specific human diseases; see my paper in the Feb 2011 issue of AJHG, in which I and my colleagues develop a proof-of-concept predictor for a specific genetic disease. Another area of research, which I am just beginning on, is attempting to understand the forces that control the evolution of protein structures, and map out the constraints that evolution places on protein structures.

Publications

  1. Jordan DM, Kiezun A, Baxter SM, Agarwala V, Green RC, Murray MF, Pugh T, Lebo MS, Rehm HL, Funke BH, and Sunyaev SR. . pmid:21310275. PubMed HubMed [HCMPrediction]
  2. Jordan DM, Ramensky VE, and Sunyaev SR. . pmid:20399638. PubMed HubMed [COSTBReview]
  3. Jordan DM, Mills KM, Andricioaei I, Bhattacharya A, Palmo K, and Zuiderweg ER. . pmid:17526036. PubMed HubMed [CSAPrediction]
All Medline abstracts: PubMed HubMed

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