User:Tkadm30/Notebook/Aripiprazole
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(Redirected from User:Etienne Robillard/Notebook/Aripiprazole)Synopsis
Phenylpiperazine derivative.
Functional selectivity of aripiprazole at D2 receptors
- Aripiprazole has functionally selective actions at dopamine D2 receptor-mediated signaling pathways.
- Protective effect of aripiprazole against glutamate cytotoxicity in dopaminergic neurons of rat mesencephalic cultures.
- Antagonism of the adenosine A2A receptor attenuates akathisia-like behavior induced with MP-10 or aripiprazole in a novel non-human primate model.
- Repeated aripiprazole treatment causes dopamine D2 receptor up-regulation and dopamine supersensitivity in young rats.
- Unique Effects of Acute Aripiprazole Treatment on the Dopamine D2 Receptor Downstream cAMP-PKA and Akt-GSK3β Signalling Pathways in Rats
- Chronic administration of aripiprazole activates GSK3β-dependent signalling pathways, and up-regulates GABAA receptor expression and CREB1 activity in rats
Aripiprazole/THC interactions
- Aripiprazole-CB1 activation may increase functional selectivity at dopamine D2 receptors? (Reference needed)
- Effects of Aripiprazole and Haloperidol on Fos-like Immunoreactivity in the Prefrontal Cortex
- https://www.mrnice.nl/forum/9-patients-forum/15829-aripiprazole-thc-interactions.html
Aripiprazole-mediated gene expression
- Update on the Mechanism of Action of Aripiprazole: Translational Insights into Antipsychotic Strategies Beyond Dopamine Receptor Antagonism.
- Chronic treatment with aripiprazole induces differential gene expression in the rat frontal cortex.
Side effects
- Worsened hypertension control induced by aripiprazole
- Dopamine supersensitivity psychosis and dopamine partial agonist: a retrospective survey of failure of switching to aripiprazole in schizophrenia.
- Akathisia
- Insomnia
- Tardive dyskinesia
- Racing thoughts
- Hyperdreaming
- Hyperprolactinemia
Notes
- Is Aripiprazole a selective FAAH inhibitor?
