User:Etienne Robillard/Notebook/Brainstorming

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Contents


Nanotoxicity of fine particulate matter

  • Metal oxide nanoparticles includes:
    • silicon dioxide
    • titanium dioxide
    • aluminium oxide
    • barium oxide
    • iron oxide
    • cadmium
    • arsenic
    • dimethyl sulfate and monomethyl sulfate[1]
  • Exposure to metal oxide NPs is nanotoxic and may cause neuroinflammation via oxidative stress. [2]
  • Coal fly ash is a source of metal oxide NPs.
  • Fine particulate matter may induce chronic COPD pathogenesis.[3]


Microglial activation

  • Activation of the microglia by aluminium nanoparticles disrupt the cytokine/neurotrophin balance.
  • Possible role of microglia-derived BDNF signaling on intracellular Ca2+ elevation? [4]

Synaptic hypercomputation

Biological utilization of quantum nonlocality:

Phase coherence of synaptic hypercomputation

Retrograde signaling and synaptogenesis regulate phase coherence (latency) of presynaptic action potential?

Retrograde signaling

Glycinergic transmission trafficking

Allosteric modulation of glycine receptors by endocannabinoids

  • THC and anandamide may modulates synaptogenesis in the retina and brain through glycinergic transmission [5]
  • Intracellular DHA delivery facilitate glutamatergic NMDA receptor function in the presence of glycine [6]
  • THC and anandamide enhance NMDA-dependent LTP through glycine receptor activation

CB1-induced cholinergic neurotransmission

  • Hypothalamic POMC neurons promote CB1-induced feeding [7]
  • Caffeine potentiate striatal neurotransmission through presynaptic CB1 receptor activation. [8]
  • Monoamine oxidase inhibition affects cannabinoid-induced synaptogenesis. [9]

intracellular CB1/BDNF signaling

  • CB1 receptor activation induce striatal neuroprotection through a PI3K/Akt/mTORC1/BDNF pathway. [10]

Political manipulations of psychiatry (Sluggish schizophrenia)

Ubiquity of consciousness

References

  1. https://www.ncbi.nlm.nih.gov/pubmed/7350652 [Paper8]
    Dimethyl and monomethyl sulfate: presence in coal fly ash and airborne particulate matter.

  2. http://particleandfibretoxicology.biomedcentral.com/articles/10.1186/1743-8977-2-10

    [Paper9]

    Combustion-derived nanoparticles: A review of their toxicology following inhalation exposure.

  3. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617054/

    [Paper10]

    Fine particulate matter in acute exacerbation of COPD.

  4. https://www.ncbi.nlm.nih.gov/pubmed/25171395

    [Paper11]

    Positive feedback loop of autocrine BDNF from microglia causes prolonged microglia activation.

  5. https://www.ncbi.nlm.nih.gov/pubmed/16332990

    [Paper2]

    Delta9-tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors.

  6. https://www.ncbi.nlm.nih.gov/pubmed/7514666

    [Paper3]

    Facilitatory effect of docosahexaenoic acid on N-methyl-D-aspartate response in pyramidal neurones of rat cerebral cortex.

  7. https://www.ncbi.nlm.nih.gov/pubmed/25707796

    [Paper4]

    Hypothalamic POMC neurons promote cannabinoid-induced feeding.

  8. https://www.ncbi.nlm.nih.gov/pubmed/19027757

    [Paper5]

    Caffeine drinking potentiates cannabinoid transmission in the striatum: interaction with stress effects.

  9. https://www.ncbi.nlm.nih.gov/pubmed/23858446

    [Paper6]

    Cognitive abnormalities and hippocampal alterations in monoamine oxidase A and B knockout mice.

  10. https://www.ncbi.nlm.nih.gov/pubmed/25698444

    [Paper7]

    The CB₁ cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway.

  11. https://www.jstage.jst.go.jp/article/jts/36/3/36_3_267/_article

    [Paper1]

    Nasal instillation of nanoparticle-rich diesel exhaust particles slightly affects emotional behavior and learning capability in rats

  12. http://pubs.rsc.org/en/content/articlelanding/2017/tx/c6tx00314a

    [Paper12]

    Synergistic effects of particulate matter (PM2.5) and sulfur dioxide (SO2) on neurodegeneration via the microRNA-mediated regulation of tau phosphorylation.

  13. http://jaapl.org/content/35/4/469

    [Paper13]

    Amnesia and Crime.

  14. http://journal.frontiersin.org/article/10.3389/fphar.2016.00355/full

    [Paper14]

    Splendor in the Grass? A Pilot Study Assessing the Impact of Medical Marijuana on Executive Function

  15. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098150/

    [Paper15]

    Possible existence of optical communication channels in the brain

See also

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