User:Etienne Robillard/Notebook/Brainstorming

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  • Important secondary messengers: NMDA, Dopamine, Serotonin, GABA, AChr, calmodulin, p38 MAP kinase
  • Sites of interests: p38 (MEK), EGFR (Fyn), c-Src homolog domain (brain/hippocampus/amygdala), Ras/Raf/MEK pathway (Bcl-2), NMDAR, NRG1
  • Cannabinoid agonists and the cholinergic system: Selective affinity for the mAChR receptor may indicates endogenous endocannabinoids as potential agents for neuroprotection agaisn't organophosphate-derived nerve gas precursors and Alzheimer disease. (EC
  • Key roles for nanoparticles based chemical inducers and repressors are multiples and under intense research including but not limited to chemotherapy, bioinformatics, and synthetic biology.
  • Endocannabinoid transport
    • retrograde 2-AG signaling may promote glutamatergic LTP. PMID
    • retrograde 2-AG signaling is ATP-dependent PMID
    • non-retrograde TRPV1 activation by endogenous anandamide transporter (neuroprotective)
    • neuron-astrocyte signaling PMID
  • Allosteric modulation of glycine receptors by endocannabinoids
    • THC and anandamide may modulates synaptogenesis in the retina and brain through glycinergic transmission PMID
    • DHA facilitate NMDA receptor activation in the presence of glycine PMID
    • THC and anandamide enhance NMDA-dependent LTP through glycine receptor activation
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