User:Etienne Robillard/Notebook/Brainstorming

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  • Key roles for nanoparticles based drug delivery systems are multiples and under intense research including but not limited to chemotherapy, bioinformatics, and synthetic biology.
    • Keywords: molecular delivery, directed molecular evolution
  • Nanoparticles can alter behavior and learning capability by modulation of monoamine neurotransmitters. [1]

Nanoparticles-mediated ultrasonic neuromodulation of brain activity

Retrograde endocannabinoid signaling

  • Allosteric modulation of glycine receptors by endocannabinoids
    • THC and anandamide may modulates synaptogenesis in the retina and brain through glycinergic transmission [2]
    • DHA facilitate NMDA receptor activation in the presence of glycine [3]
    • THC and anandamide enhance NMDA-dependent LTP through glycine receptor activation

Cannabinoid-induced cholinergic neurotransmission

  • Hypothalamic POMC neurons promote CB1-induced feeding [4]
  • Caffeine potentiate striatal neurotransmission through presynaptic CB1 receptor activation. [5]
  • Monoamine oxidase inhibition affects cannabinoid-induced synaptogenesis. [6]

Sluggish schizophrenia; political manipulations of psychiatry

  • Schizophrenia is a man-made disease; Its goal is to control consciousness based on subjectives views of psychology.
    • Schizophrenia is a scam to alter consciousness with antipsychotics; It is a deliberate attempt to alienate creativity of the mind with synthetic chemicals and destroy consciousness.
  • "Psychiatry as a means of intimidation": The bliss of ignorance is deeper in the region of tyranny.

Theories of consciousness


  1. [Paper1]
    Nasal instillation of nanoparticle-rich diesel exhaust particles slightly affects emotional behavior and learning capability in rats

  2. Hejazi N, Zhou C, Oz M, Sun H, Ye JH, and Zhang L. . pmid:16332990. PubMed HubMed [Paper2]
    Delta9-tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors.

  3. Nishikawa M, Kimura S, and Akaike N. . pmid:7514666. PubMed HubMed [Paper3]
    Facilitatory effect of docosahexaenoic acid on N-methyl-D-aspartate response in pyramidal neurones of rat cerebral cortex.

  4. Koch M, Varela L, Kim JG, Kim JD, Hernández-Nuño F, Simonds SE, Castorena CM, Vianna CR, Elmquist JK, Morozov YM, Rakic P, Bechmann I, Cowley MA, Szigeti-Buck K, Dietrich MO, Gao XB, Diano S, and Horvath TL. . pmid:25707796. PubMed HubMed [Paper4]
    Hypothalamic POMC neurons promote cannabinoid-induced feeding.

  5. Rossi S, De Chiara V, Musella A, Mataluni G, Sacchetti L, Siracusano A, Bernardi G, Usiello A, and Centonze D. . pmid:19027757. PubMed HubMed [Paper5]
    Caffeine drinking potentiates cannabinoid transmission in the striatum: interaction with stress effects.

  6. Singh C, Bortolato M, Bali N, Godar SC, Scott AL, Chen K, Thompson RF, and Shih JC. . pmid:23858446. PubMed HubMed [Paper6]
    Cognitive abnormalities and hippocampal alterations in monoamine oxidase A and B knockout mice.

All Medline abstracts: PubMed HubMed
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