Intracellular anandamide trafficking as a promoter of neural differentiation acting through selective CB1 binding
The maturation of neural stem cells via fatty-acid binding proteins (FABPs) signaling may require anandamide as a promoter of CB1-dependent neural differentiation. 
Differentiation of hippocampal stem cells with synaptamide is induced by intracellular and selective CB1 receptor binding to anandamide. 
- Allosteric activation of PPAR-RXR heterodimer by anandamide (CB1/TRPV1 receptors) facilitate hippocampal neurogenesis.
- Intracellular FABP5 expression result in anandamide trafficking of heteromeric CB1 receptor.
- Adenosine antagonism potentiate organized trafficking of anandamide via heteromization of CB1 receptor.